NCT07523035Not yet recruiting
Colorectal Adenoma Cohort
An Ambidirectional Cohort Study on Colorectal Adenoma
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
This is an ambidirectional cohort study aiming to develop and validate a risk prediction model for colorectal adenoma recurrence and progression. The study will enroll patients aged 18-75 years who undergo colorectal adenoma resection at the Second Affiliated Hospital of Zhejiang University School of Medicine. A retrospective cohort will include patients treated in the past 10 years with available endoscopic, pathologic, and routine laboratory data. A prospective cohort will be enrolled from the date of ethical approval until December 31, 2030, with collection of epidemiological questionnaire data, lifestyle information, blood and tissue biospecimens, and follow-up outcomes. The primary outcome is adenoma recurrence, with secondary outcomes including advanced adenoma and colorectal cancer. Based on a target of 1,083 evaluable participants (325 events) to ensure adequate model development, and accounting for 15% loss to follow-up, the total planned enrollment is 1,280 participants. The study will validate existing risk models based on traditional adenoma characteristics and establish a novel model incorporating lifestyle factors and systemic inflammatory markers to improve risk stratification and guide surveillance strategies.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 1280 (estimated)
- First submitted
- 5 Apr 2026
- Start date
- 16 Apr 2026
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Diseases
- Colorectal cancer
- NCT number
- NCT07523035
What you commit to
- Study type: Observational
- Planned participants: 1280
- From 16 Apr 2026 to the primary completion date, 31 Dec 2030
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent receipt of radiotherapy or chemotherapy.
Other illness
- Severe dysfunction of vital organs (e.g., heart, liver, kidney).
- Psychiatric disorders that preclude normal communication or compliance with study procedures.
- History of colorectal cancer.
Other
- Pregnancy or lactation.
Who the study is looking for
- Patients who underwent colonoscopy at our institution, were diagnosed with colorectal adenoma, and underwent adenoma resection.
- Aged between 18 and 75 years.
- Provide written informed consent voluntarily, with willingness to comply with follow-up procedures.
- For the retrospective cohort only: Regular follow-up colonoscopy at our institution within 1 to 5 years after adenoma resection.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.