NCT07524426Recruiting
Local Radiotherapy for Urinary Bladder Cancer in Patients Not Eligible for Curative Treatment
Local Radiotherapy for Urinary Bladder Cancer in Patients Not Eligible for Curative Treatment; a Prospective Randomized Phase III Trial.
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to improve the quality of life and prolong survival in bladder cancer patients unfit for curative treatment. The trial will compare the survival and symptoms of patients randomized to either local radiotherapy in addition to standard of care or standard of care alone. Using modern radiotherapy techniques, including hypofractionation and image-guided treatment adaptation, the aim is to deliver a well-tolerated, time-efficient, and effective treatment strategy for these patients. The trial collaborates with two ongoing exploratory biomarker studies collecting and analyzing potential biomarkers in urothelial bladder cancer. The hope is to provide biomarkers for prognosis and treatment response which is essential to ensure bladder cancer patients individualized treatment in the future, like those with breast and prostate cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 248 (estimated)
- First submitted
- 24 Mar 2026
- Start date
- 3 Jun 2026
- Primary completion date
- 30 Jun 2032
- Lead sponsor
- Umeå University
- Diseases
- Bladder cancer
- NCT number
- NCT07524426
What you commit to
- Study type: Interventional
- Planned participants: 248
- From 3 Jun 2026 to the primary completion date, 30 Jun 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous pelvic RT with significant overlap
Other
- Clinical Fragility Scale score ≥8
- Visceral or bone metastases on CT scan
- Multiple (\>3) lymph node metastases with a measurement of \>2 cm on CT scan
- Planed for systemic treatment at the time of inclusion.
- Local RT to the bladder indicated for the palliation of symptoms at the time of inclusion.
Who the study is looking for
- Oral and written consent
- Histologically confirmed MIBC with urothelial component
- Male or female participants ≥ 18 years old
- Deemed not to benefit from curative treatment at a multidisciplinary tumour conference (MDT) or having declined curative treatment of their own accord.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Norrlands University Hosital Coordinator of this site? Confirm its status | Umeå | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.