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NCT07524491Completed

taVNS During Exercise and Recovery in Chronic Spinal Cord Injury

Transcutaneous Auricular Vagus Nerve Stimulation Modulates Autonomic Dynamics During Exercise and Recovery in Chronic Spinal Cord Injury

Source: ClinicalTrials.gov · Last updated 13 Apr 2026

Brief summary (registry, in English)

This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI). Participants undergo two experimental conditions (active taVNS and sham stimulation) in a randomized crossover design while performing a standardized exercise protocol. Heart rate variability (HRV) is used as a non-invasive biomarker to assess autonomic nervous system dynamics across different phases (baseline, exercise, and recovery). The aim is to characterize physiological responses to neuromodulation and explore whether taVNS modulates autonomic adaptability in this population. This is a mechanistic physiological study designed to improve the understanding of autonomic regulation in SCI and to explore potential biomarkers of response to neuromodulation.

Status (registry)
Completed
Study type
Interventional
Enrollment
35 (actual)
First submitted
17 Mar 2026
Start date
31 Oct 2024
Primary completion date
31 Oct 2024
Lead sponsor
University of the Balearic Islands
NCT number
NCT07524491

What you commit to

  • Study type: Interventional
  • Participants enrolled: 35
  • From 31 Oct 2024 to the primary completion date, 31 Oct 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Use of medications significantly affecting autonomic function

Other illness

  • Cognitive impairment preventing protocol compliance

Other

  • Acute spinal cord injury
  • Severe cardiovascular or respiratory instability
  • Skin lesions or contraindications to transcutaneous stimulation

Who the study is looking for

  • Adults (≥18 years) with chronic spinal cord injury
  • Medically stable condition
  • Ability to perform the exercise protocol
  • Ability to provide informed consent

Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of the Balearic Islands
Coordinator of this site? Confirm its status
Palma de MallorcaSpainUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.