NCT07524491Completed
taVNS During Exercise and Recovery in Chronic Spinal Cord Injury
Transcutaneous Auricular Vagus Nerve Stimulation Modulates Autonomic Dynamics During Exercise and Recovery in Chronic Spinal Cord Injury
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI). Participants undergo two experimental conditions (active taVNS and sham stimulation) in a randomized crossover design while performing a standardized exercise protocol. Heart rate variability (HRV) is used as a non-invasive biomarker to assess autonomic nervous system dynamics across different phases (baseline, exercise, and recovery). The aim is to characterize physiological responses to neuromodulation and explore whether taVNS modulates autonomic adaptability in this population. This is a mechanistic physiological study designed to improve the understanding of autonomic regulation in SCI and to explore potential biomarkers of response to neuromodulation.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 35 (actual)
- First submitted
- 17 Mar 2026
- Start date
- 31 Oct 2024
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- University of the Balearic Islands
- NCT number
- NCT07524491
What you commit to
- Study type: Interventional
- Participants enrolled: 35
- From 31 Oct 2024 to the primary completion date, 31 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of medications significantly affecting autonomic function
Other illness
- Cognitive impairment preventing protocol compliance
Other
- Acute spinal cord injury
- Severe cardiovascular or respiratory instability
- Skin lesions or contraindications to transcutaneous stimulation
Who the study is looking for
- Adults (≥18 years) with chronic spinal cord injury
- Medically stable condition
- Ability to perform the exercise protocol
- Ability to provide informed consent
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of the Balearic Islands Coordinator of this site? Confirm its status | Palma de Mallorca | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.