NCT07525505Recruiting
Nigella Sativa Oil for Eczematous Otitis Externa
Efficacy of Nigella Sativa Oil in Eczematous Otitis Externa: A Randomized Controlled Study
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
Eczematous otitis externa is a common inflammatory condition of the external auditory canal characterized by itching, discomfort, discharge, and pain. Topical corticosteroids are widely used for treatment; however, alternative therapies with fewer side effects are of increasing interest. This study aims to compare the efficacy of Nigella sativa (black seed) oil and mometasone furoate ear drops in the treatment of eczematous otitis externa. Nigella sativa is a natural product with known anti-inflammatory and antimicrobial properties. In this randomized, controlled clinical trial, adult patients with eczematous otitis externa will be assigned to receive either Nigella sativa oil or mometasone furoate ear drops for 10 days. Clinical symptoms and inflammatory findings will be evaluated at baseline and after treatment. The objective of this study is to determine whether Nigella sativa oil is an effective and safe alternative to topical corticosteroid therapy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 85 (estimated)
- First submitted
- 7 Apr 2026
- Start date
- 12 Jan 2026
- Primary completion date
- Jun 2026
- Lead sponsor
- Bezmialem Vakif University
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT07525505
What you commit to
- Study type: Interventional
- Planned participants: 85
- From 12 Jan 2026 to the primary completion date, Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of topical or systemic corticosteroids or other ear medications within a defined period prior to enrollment
Other illness
- Known hypersensitivity or allergic reaction to Nigella sativa oil or mometasone furoate
- History of ear surgery or structural abnormalities of the external auditory canal
- Severe systemic disease or condition that may interfere with study participation
Other
- Presence of acute otitis externa of infectious origin requiring antibiotic treatment
- Pregnant or breastfeeding women
Who the study is looking for
- Adult patients aged 18 years and older
- Clinical diagnosis of eczematous otitis externa confirmed by otoscopic examination
- Presence of at least one symptom related to the affected ear (itching, discomfort, otorrhea, or pain)
- Willingness to participate and ability to provide written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bezmialem Vakif University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.