NCT07526454Completed
Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder
Comparative Efficacy of Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
This study aimed to compare the efficacy, safety, and tolerability of electroconvulsive therapy (ECT) versus intravenous (IV) ketamine in adults with treatment-resistant major depressive disorder (TRD).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 70 (actual)
- First submitted
- 6 Apr 2026
- Start date
- 1 Jul 2025
- Primary completion date
- 1 Feb 2026
- Lead sponsor
- Tanta University
- Diseases
- Depression
- NCT number
- NCT07526454
What you commit to
- Study type: Interventional
- Participants enrolled: 70
- From 1 Jul 2025 to the primary completion date, 1 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of psychotic disorders or bipolar disorder.
- Current substance use disorder.
- Significant neurological disorders or traumatic brain injury.
- cardiovascular diseases in the past six months.
Other
- Uncontrolled hyper- tension.
- Pregnancy or breastfeeding.
Who the study is looking for
- Adults aged 18-75 years.
- Current diagnosis of major depressive disorder (MDD) according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
- Treatment resistance defined as failure to respond to ≥2 adequate antidepressant trials in the current episode.
- Montgomery-Åsberg Depression Rating Scale (MADRS) score ≥20.
- Capacity to provide informed consent.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tanta university Coordinator of this site? Confirm its status | Tanta | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.