NCT07527156RecruitingPhase 4
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Feasibility and Safety of Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Source: ClinicalTrials.gov · Last updated 14 Apr 2026
Brief summary (registry, in English)
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 7 Apr 2026
- Start date
- 4 Apr 2026
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Institute for Clinical and Experimental Medicine
- Diseases
- Heart failure
- NCT number
- NCT07527156
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 12
- From 4 Apr 2026 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe liver failure
Other
- Severe acidosis
- Inability to insert nasogastric tube
- Gastric paralysis / ileus
- Repeated vomiting
- Severe hypokalemia
Who the study is looking for
- LVEF \<35%
- Acute heart failure with low cardiac output syndrome or cardiogenic shock
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute for Clinical and Experimental Medicine (IKEM) Coordinator of this site? Confirm its status | Prague | Czechia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.