NCT07529041Enrolling by invitation
Real-time Acoustic Biofeedback for Enhancing Fixation Stability: A Proof-of-concept Study to Improve Ophthalmic Imaging Diagnostic Quality
Source: ClinicalTrials.gov · Last updated 14 Apr 2026
Brief summary (registry, in English)
The goal of this Proof of Concept Feasibility Study is to improve the fixation stability in patients with fixation loss due to blindness or central vision loss using a patented acoustic real-time feedback device. The main questions it aims to answer are: 1. Fixation guidance - can real-time acoustic biofeedback improve the fixation in healthy patients as well as patients with fixation loss? 2. Optimization of fixation guidance - testing of different stimuli to optimize an acoustic training protocol. 3. Optimization of imaging acquisition - testing improvement of both imaging quality and acquisition time using the acoustic feedback tool. For the proof-of-concept-study, patients are asked to fixate on a target point in a darkened room and keep up the fixation. We record patients eye movements with near-infrared-lighting and a camera. Fixation is tested in three conditions - visual target only, auditory feedback only, and visual target followed by auditory feedback. In between each set of trials, patients are asked to rate their subjective exhaustion on a Likert scale. At the end of each recording session, patients are handed a questionnaire for feedback on our proof-of-concept study and device settings. An ethics-approved extension phase is planned to further optimize device parameters and assess performance in a clinical setting.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 22 (estimated)
- First submitted
- 24 Mar 2026
- Start date
- Aug 2025
- Primary completion date
- Apr 2026
- Lead sponsor
- University Medical Center Goettingen
- Diseases
- Macular degeneration
- NCT number
- NCT07529041
What you commit to
- Study type: Interventional
- Planned participants: 22
- From Aug 2025 to the primary completion date, Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- age below 18 years
Other
- lack of ability to consent to participate in study
- reduced cooperation during examination or recording
- inability to perceive auditory feedback
- patients with nystagmus or inability to move eyes
- opacity of cornea or other ocular structures preventing successful eye tracking
- inability to communicate
Who the study is looking for
- Healthy participants:
- minimum age of 18 years
- no neurological or ophthalmological disease
- ability to perceive auditory feedback
- normal vision
- consent to participate in study
- Patients:
- minimum age of 18 years
- existing ophthalmological diagnosis of fixation deficite or loss
- ability to perceive auditory feedback
- consent to participate in study
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| EKFZ Else Kroener Fresenius Center for Optogenetic Therapies, University Medical Center Goettingen Coordinator of this site? Confirm its status | Göttingen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.