NCT07531264Not yet recruitingEarly phase 1
Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction in Chronic Stroke
Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation
Source: ClinicalTrials.gov · Last updated 18 Jun 2026
Brief summary (registry, in English)
The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate motor modules through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 22 Oct 2025
- Start date
- 1 Aug 2027
- Primary completion date
- 31 Aug 2032
- Lead sponsor
- University of Houston
- Diseases
- Stroke
- NCT number
- NCT07531264
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 48
- From 1 Aug 2027 to the primary completion date, 31 Aug 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals with an orthopedic disorder involving the upper limbs
- Individuals with cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol, assessed using the Montreal Cognitive Assessment or other IRB-approved screening procedures.
- Individuals whose stroke-affected arm has an intermuscular coordination pattern similarity score \>0.80 relative to the non-affected arm
- Individuals with known neurological disorders
- Individuals with orthopedic injuries or conditions affecting upper-extremity movement
Age
- Individuals younger than 21 years of age or older than 80 years of age
- Individuals younger than 21 years of age or older than 80 years of age
Other
- Individuals unable to produce voluntary upper-extremity muscle EMG activity;
- Individuals unable to provide informed consent
Who the study is looking for
- Hemiparetic chronic stroke survivors more than 6 months after stroke onset
- Adults aged 21-80 years, including both female and male participants
- Individuals with a single unilateral ischemic or hemorrhagic stroke
- Individuals with Upper Extremity Fugl-Meyer Assessment score between 10 and 59 out of 66
- Individuals who have not received botulinum toxin injections in the upper extremity within the past 3 months
- Individuals without severe spasticity, defined as Modified Ashworth Scale score ≤3 at the elbow and shoulder
- Healthy adults aged 21-80 years, including both female and male participants
- Individuals with no known neurological or orthopedic injuries
Age in the registry: 21 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.