NCT07531927Recruiting
Safety and Clinical Applicability of Transcorneal Electrical Stimulation (TES) in Geographic Atrophy
Safety and Clinical Applicability of Transcorneal Electrical Stimulation (TES) in Geographic Atrophy Under Everyday Conditions - a Multicentric, Randomized, Double-masked, Sham-controlled Pilot Study
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
Geographic atrophy (GA) is a progressive eye disease that causes the degeneration of the retinal cells, particularly in the macula, leading to vision loss. The goal of this pilot study is to evaluate the safety and the effectiveness of transcorneal electrical stimulation (TES) therapy with the OkuStim 2 System in patients with geographic atrophy (GA). Researchers will compare the effects of two different electrical stimuli with a placebo to see if the stimuli are safe and can slow down the progression of the disease. Participants will be randomly assigned to one of these three groups: * TES-treatment with a rectangular stimulus * TES-treatment with a repetitive ramp stimulus * Placebo (sham) treatment Participants will apply the therapy at home, once a week for 30 minutes each over a duration of 1 year.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 27 Mar 2026
- Start date
- 5 May 2026
- Primary completion date
- Jun 2028
- Lead sponsor
- Okuvision GmbH
- Diseases
- Macular degeneration
- NCT number
- NCT07531927
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 5 May 2026 to the primary completion date, Jun 2028
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous major eye surgeries (including retinal surgery or vitrectomy)
- Previous laser treatment or injections in the study eye
- Planned eye surgery during the study period
- Recent treatment with investigational drugs for geographic atrophy
- Presence of active medical implants
Other illness
- History or presence of certain eye conditions (e.g. macular edema, abnormal blood vessel growth or related conditions, retinal detachment, blood vessel blockage) in the study eye
- Any other eye condition that could interfere with vision tests, imaging or study results
- Serious or uncontrolled systemic diseases, history of epilepsy or poor general health or conditions affecting the ability to follow study procedures
- Breastfeeding, relevant allergies (e.g. to silver), or heavy smoking
Other
- Participation in another clinical study recently or at the same time
Who the study is looking for
- Willing and able to understand the study and provide informed consent
- 60 years of age or older
- Diagnosis of geographic atrophy due to age-related macular degeneration confirmed by imaging
- The affected area in the eye must be within a defined size range and clearly visible on imaging
- Eye conditions must allow for good-quality images and reliable measurements
- Must have a minimum level of visual acuity
- Women of childbearing potential must have a negative pregnancy test, and must agree to use effective contraception during the study (women who are postmenopausal or surgically sterile are not subject to pregnancy-related requirements)
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Ophthalmology, University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Department of Ophthalmology, Ludwig-Maximilians-University Munich Coordinator of this site? Confirm its status | München | Germany | Recruiting |
| Department of Ophthalmology, Klinikum Stuttgart Coordinator of this site? Confirm its status | Stuttgart | Germany | Recruiting |
| Centre for Ophthalmology, University Hospital Tuebingen Coordinator of this site? Confirm its status | Tübingen | Germany | Recruiting |
| Department of Ophthalmology, University Hospital Ulm Coordinator of this site? Confirm its status | Ulm | Germany | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.