NCT07534124Completed
Virtual Reality-Based Upper Limb Rehabilitation in Chronic Stroke
Non-Immersive Virtual Reality (MindMotion™ GO) Improves Upper Limb Motor Function in Chronic Left MCA Stroke: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
This randomized controlled study aims to evaluate the effectiveness of non-immersive virtual reality-based rehabilitation using the MindMotion™ GO system compared with conventional occupational therapy for improving upper limb motor function in individuals with chronic stroke. Stroke is a leading cause of long-term disability in adults worldwide, and barriers such as limited access to rehabilitation services, low motivation, and reduced adherence may hinder recovery in the chronic phase. Participants will be randomly assigned to either an experimental group receiving non-immersive virtual reality training or a control group receiving conventional occupational therapy according to standard clinical practice. Both groups will complete two rehabilitation sessions per week for eight weeks, with each session lasting approximately 40 minutes. The study will assess upper limb motor function, performance in activities of daily living, and quality of life. In addition, electroencephalography (EEG) will be used before and after the intervention to explore potential neuroplastic changes associated with rehabilitation. Outcome assessments will be conducted at baseline and at follow-up approximately three months after the initial evaluation. The results of this study may help determine whether non-immersive virtual reality is an effective and accessible tool to enhance rehabilitation outcomes in individuals with chronic stroke.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 9 Apr 2026
- Start date
- 1 Sept 2022
- Primary completion date
- 30 May 2025
- Lead sponsor
- Universidad Complutense de Madrid
- Diseases
- Stroke
- NCT number
- NCT07534124
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 1 Sept 2022 to the primary completion date, 30 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in other upper limb rehabilitation therapies during the study period.
- Severe functional dependency prior to stroke.
Other illness
- Participants will be excluded if any of the following conditions are present:
- Severe cognitive impairment (Montreal Cognitive Assessment score \<10).
- Major depression or emotional disorders associated with severe attention or cooperation deficits that may interfere with hand function.
- Severe psychiatric disease.
- History of other strokes occurring after the index stroke.
- Any medical condition that, in the opinion of the investigator, could interfere with study participation or data interpretation.
Other
- Severe spasticity in the affected limb (Modified Modified Ashworth Scale ≥3-4).
- Aphasia preventing comprehension of verbal instructions.
- Visuospatial neglect preventing interaction with the rehabilitation interface.
Who the study is looking for
- Participants must meet all of the following criteria:
- Age between 18 and 80 years.
- Chronic phase of ischemic stroke affecting the dominant hemisphere in the Middle Cerebral Artery territory (more than 6 months and less than 4 years since stroke onset).
- Ability to actively extend the wrist at least 20 degrees and extend the fingers at least 10 degrees.
- Upper limb muscle strength of the paretic limb ≥2 in the shoulder, elbow, and wrist.
- Adequate trunk control.
- Adequate vision and hearing to interact with the rehabilitation platform.
- Ability to collaborate and follow study procedures.
- Meeting safety criteria for Electroencephalography recording.
- Signed informed consent.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Complutense University of Madrid Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.