NCT07535723Not yet recruiting
Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 28 Mar 2026
- Start date
- Apr 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Beni-Suef University
- Diseases
- Migraine
- NCT number
- NCT07535723
What you commit to
- Study type: Interventional
- Planned participants: 90
- From Apr 2026 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with BoNT-A or GONB for headache within the previous 3 months.
Other illness
- Known hypersensitivity to BoNT-A or local anesthetics.
- Neuromuscular junction disorders (e.g., myasthenia gravis).
- Coagulation disorders or anticoagulant therapy that contraindicates nerve block.
- Significant psychiatric comorbidity that would impair proper pre and post treatment assessment.
Other
- Co-morbid other
- Cervical anatomical abnormalities that hinder proper localization of injection sites or compromise the safety of the procedure
- Pregnancy.
Who the study is looking for
- Diagnosis of chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3): headache occurring on ≥15 days per month for more than three months, with at least 8 days per month exhibiting migraine features. (International Headache Society, 2013)
- Age \> 18 years
- Stable preventive migraine regimen for at least two months prior to recruitment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beni-Suef University Hospital Coordinator of this site? Confirm its status | Al Fayyum | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.