NCT07537491Recruiting
KIA-Korekt: Staged Unimodal-to-Multimodal AI Evaluation for Perioperative Risk Prediction in Colorectal Cancer
Staged Unimodal-to-Multimodal AI Analysis of Histopathology, CT/MRI, and Multiplex Tissue Imaging for Perioperative Risk Prediction in Colorectal Cancer (KIA-Korekt)
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
Perioperative complications following surgery for colorectal cancer (CRC) represent a major cause of postoperative morbidity and mortality. Existing risk stratification tools lack the precision to capture the complex biological and morphological factors that determine individual patient vulnerability. Artificial intelligence (AI)-based analysis of medical imaging data offers a promising approach to improve preoperative risk prediction. The KIA-Korekt study investigates whether perioperative complications in CRC patients can be predicted using multimodal AI-based image analysis. Three complementary imaging modalities are integrated: digital histopathology (haematoxylin-eosin whole-slide images, H\&E-WSIs), preoperative CT and MRI radiomics, and multiplex tissue imaging (mTI) including multiplex immunohistochemistry (mIHC) and imaging mass cytometry (IMC). The study includes a retrospective cohort of approximately 750 CRC patients treated between 2011 and 2021, and a prospective validation cohort of approximately 210 patients recruited from 2026 to 2028. Deep learning and radiomic feature extraction pipelines are applied to all modalities individually and in multimodal combination. Predicted outcomes include anastomotic leakage, wound infection, sepsis, ICU admission, and in-hospital mortality within 30 days of surgery. The study is conducted at the University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane, in collaboration with the Department of Computational Pathology, TU Dresden.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 910 (estimated)
- First submitted
- 8 Apr 2026
- Start date
- 1 Jan 2011
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Rene Mantke
- Diseases
- Colorectal cancer
- NCT number
- NCT07537491
What you commit to
- Study type: Observational
- Planned participants: 910
- From 1 Jan 2011 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients not undergoing surgical treatment
Other
- Missing H\&E-stained tissue slides of the primary tumour
- Histopathological material of insufficient quality for analysis
Who the study is looking for
- Adult patients (≥18 years)
- Histologically confirmed colorectal adenocarcinoma
- Undergoing surgical resection (curative or palliative intent)
- Availability of H\&E-stained whole-slide images (WSIs) from the primary tumour
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Brandenburg an der Havel, Brandenburg an der Havel, Germany (Single-center) Coordinator of this site? Confirm its status | Brandenburg an der Havel | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.