NCT07539675Recruiting
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 20 Mar 2026
- Start date
- 1 Oct 2025
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Zhongnan Hospital
- Diseases
- Glaucoma
- NCT number
- NCT07539675
What you commit to
- Study type: Observational
- Planned participants: 150
- From 1 Oct 2025 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous intraocular surgery
- Long-term use of medications affecting connective tissue metabolism
Other illness
- Systemic diseases that can cause abnormal ocular zonules
- Other severe ocular diseases
Other
- Secondary glaucoma
Who the study is looking for
- Clinically diagnosed with primary angle-closure glaucoma (PACG)
- Aged ≥ 50 years, no gender restriction
- Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
- Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
- Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongnan Hospital of Wuhan University Coordinator of this site? Confirm its status | Wuhan | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.