NCT07539766Recruiting
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
OBESE-HFpEF: Prevalence and Mediators of Heart Failure (Preserved Ejection Fraction) in the Dutch Obesity Clinic South - Towards Preventing Obesity Related HFpEF''
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer. This makes it harder for the heart to fill with blood, which can lead to shortness of breath during physical activity. In the Netherlands, 15% of the population has obesity. In South Limburg, this is even higher at 19%. Among people with HFpEF, obesity is much more common: about 50% of these patients have obesity. Life expectancy in people with HFpEF is poor, and current treatment mainly focuses on reducing symptoms. Early recognition and treatment of risk factors, such as obesity, are therefore very important. This study includes about 250 people with obesity. Using a heart ultrasound and tests of blood and fat tissue, we will look for early signs of HFpEF and study the effects of weight loss. The measurements will be repeated after 1 and 2 years. The goal of this study is to better understand how obesity contributes to HFpEF and how weight loss affects the heart. This research may help improve future treatments for patients with HFpEF.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 30 Jan 2026
- Start date
- 1 Jan 2025
- Primary completion date
- 1 May 2028
- Lead sponsor
- Zuyderland Medisch Centrum
- Diseases
- Heart failure, Obesity
- NCT number
- NCT07539766
What you commit to
- Study type: Observational
- Planned participants: 250
- From 1 Jan 2025 to the primary completion date, 1 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Inability of undergoing metabolic bariatric surgery safely.
- A medical history of previous metabolic bariatric surgery.
Lab values
- A medical history of a reduced LVEF at any time, history of severe cardiac valve defects or severe congenital cardiac defects.
Other
- Inability to provide informed consent.
- A BMI \>60 kg/m2
- Inability to undergo the study measurement/tests.
- Not proficient in the Dutch language
Who the study is looking for
- Age ≥ 35 years
- Eligible for surgical treatment for obesity, according to the Dutch guideline, i.e. a BMI ≥ 40 kg/m2 or a BMI ≥ 35 kg/m2 with one or more comorbidities associated with obesity. (23)
Age in the registry: 35 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zuyderland Medisch Centrum - Heerlen Coordinator of this site? Confirm its status | Heerlen | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.