NCT07542093Not yet recruiting
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients
Use of Bedside Lung Ultrasound to Monitor Lung Recruitment Maneuvers During Mechanical Ventilation in Obese Patients
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening. This prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time. During the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg/m²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a "Total Lung Ultrasound Score," the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's "optimal PEEP" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs open after the maneuver is complete, thereby improving oxygenation and minimizing the risk of lung injury.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 45 (estimated)
- First submitted
- 14 Apr 2026
- Start date
- May 2026
- Primary completion date
- May 2027
- Lead sponsor
- Assiut University
- Diseases
- Obesity
- NCT number
- NCT07542093
What you commit to
- Study type: Observational
- Planned participants: 45
- From May 2026 to the primary completion date, May 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active bronchopleural fistula
- Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated
Other
- Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers)
- Severe hemodynamic instability: MAP \< 60 mmHg or requiring high-dose vasopressors (norepinephrine \> 0.3 mcg/kg/min)
- Raised intracranial pressure (ICP) or known severe traumatic brain injury
- Confirmed ARDS with PaO₂/FiO₂ ratio \< 100 mmHg (severe ARDS, where recruitment strategy differs significantly)
- Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment
- Refusal of consent
Who the study is looking for
- Adult patients aged \>18 years
- BMI ≥ 33 kg/m² (morbid obesity)
- Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission)
- Expected duration of mechanical ventilation ≥ 6 hours
- Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support
- SpO₂ ≥ 85% on current ventilator settings
- Written informed consent obtained from patient or legal guardian
Age in the registry: 18 years to - · Sex: All
This page is information, not medical advice. Discuss any trial with your doctor.