NCT07542171Recruiting
Clinical Outcomes After Non-curative Endoscopic Resection in Early Colorectal Cancer: A Multicenter Study
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection. Patients with non-curative resection following endoscopic treatment will be enrolled across multiple centers and managed according to real-world clinical decisions, including additional surgery or surveillance. Baseline demographic, endoscopic, and pathological characteristics will be systematically collected. The primary objective is to compare recurrence and survival outcomes between different management strategies. Secondary objectives include identifying prognostic factors associated with recurrence and developing a risk stratification model to guide individualized treatment decisions. All participants will undergo standardized follow-up according to clinical guidelines. This study is expected to provide real-world evidence to refine risk assessment, reduce unnecessary surgery, and improve personalized management for patients with early colorectal cancer after non-curative endoscopic resection.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 14 Apr 2026
- Start date
- Sept 2025
- Primary completion date
- Sept 2028
- Lead sponsor
- Nanfang Hospital, Southern Medical University
- Diseases
- Colorectal cancer
- NCT number
- NCT07542171
What you commit to
- Study type: Observational
- Planned participants: 400
- From Sept 2025 to the primary completion date, Sept 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who received neoadjuvant therapy before endoscopic resection;
Other illness
- Patients with synchronous advanced colorectal cancer or distant metastasis at baseline;
- History of other active malignancies;
- Patients with inflammatory bowel disease, familial adenomatous polyposis, or other hereditary colorectal cancer syndromes;
Other
- Incomplete pathological data or missing key variables;
- Loss to follow-up or follow-up duration less than 6 months.
Who the study is looking for
- Age ≥18 years;
- Patients with early colorectal cancer confirmed by histopathology;
- Patients who underwent endoscopic resection (including EMR, ESD, or equivalent techniques);
- Pathological diagnosis indicating non-curative resection, defined by the presence of at least one of the following: positive resection margin, submucosal invasion depth \>1000 μm, poor differentiation, lymphovascular invasion, perineural invasion, or high-grade tumor budding;
- Availability of complete clinicopathological and follow-up data;
- Patients managed with either additional surgery or surveillance after endoscopic resection.
Age in the registry: 18 years to 75 years · Sex: All
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanfang Hospital, Southern Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
| The Second Affiliated Hospital of Guangzhou Medical University Coordinator of this site? Confirm its status | Haizhu | China | Recruiting |
| Shenzhen Longgang District People's Hospital Coordinator of this site? Confirm its status | Shenzhen | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.