NCT07542340Not yet recruiting
Effect of Osteopathic Intervention on Migraine
Effect of Osteopathic Intervention on Migraine: A Randomised Controlled Trial
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia. Its pathophysiology involves activation of the trigeminovascular system, neuro-inflammation, and nervous system sensitisation. Due to the convergence of trigeminal and cervical nerves in the upper neck (C2), manual therapy may influence migraine symptoms. Osteopathic techniques, such as suboccipital inhibition and C2 manipulation, aim to reduce pain intensity and frequency by normalising mobility and reducing nociceptive stimulation. While promising, further research is needed to validate these interventions through rigorous clinical trials.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 19 Feb 2026
- Start date
- Jun 2026
- Primary completion date
- Aug 2026
- Lead sponsor
- Escola Superior de Tecnologia da Saúde do Porto
- Diseases
- Migraine
- NCT number
- NCT07542340
What you commit to
- Study type: Interventional
- Planned participants: 45
- From Jun 2026 to the primary completion date, Aug 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- radiotherapy/chemotherapy treatment currently active or within 6 months of the last session (Croibier, 2005);
- anticoagulant medication, vitamin K, treatment with corticosteroids, analgesics, and NSAIDs 10 to 15 days per month (Bigal et al., 2008; Croibier, 2005; International Headache Society (IHS), 2018).
Other illness
- recent traumas not investigated by complementary examinations, clinical history of cranio-cervical traumas, such as fracture, dislocation, and ligament rupture (Ricard \& Sallé, 2010; Croibier, 2005);
- contagious disease, such as tuberculosis (Croibier, 2005);
- cardiovascular diseases, such as severe arterial hypertension, venous thrombosis, myocardial infarction, angina pectoris, recent stroke, intracranial arterial aneurysm (Croibier, 2005);
Other
- tumours, meningitis, neuropraxia, disc herniation, or cervical hemivertebra (Ricard \& Sallé, 2010; Croibier, 2005);
- advanced osteoporosis (Croibier, 2005);
Who the study is looking for
- Age between 18 and 50 years.
- Presented five or more migraine episodes according to the criteria established by Monteiro et al. (2009), namely headache episodes with a minimum duration of 4 hours, unilateral location, pulsating character, photophobia, phonophobia, nausea, and vomiting.
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.