NCT07546721Not yet recruiting
Exercise Training for People With Advanced Multiple Sclerosis
Exercise Training for People With Advanced Multiple Sclerosis: A Feasibility Study to Inform Intervention Development
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
The goal of this interventional study is to test the feasibility of 12 weeks of aerobic exercise for people with advanced multiple sclerosis (i.e., wheelchair users). The main questions it aims to answer are: * Is the exercise intervention feasible in terms of study processes, resources, management, safety, and acceptability? * Can the intervention improve aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, and sensation? * What are participants' experiences of taking part in the exercise intervention? Participants will take part in moderate-intensity aerobic exercise twice a week for 12 weeks in a supervised research setting. Outcomes will be measured at baseline (0 weeks), mid-intervention (6 weeks), post-intervention (12 weeks), and 12-weeks after the intervention (24 weeks). The outcomes include feasibility measures, aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, sensation, and participant experiences of taking part in the exercise intervention.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 12 Mar 2026
- Start date
- 1 May 2026
- Primary completion date
- 1 Mar 2027
- Lead sponsor
- University of Ottawa
- Diseases
- Multiple sclerosis
- NCT number
- NCT07546721
What you commit to
- Study type: Interventional
- Planned participants: 12
- From 1 May 2026 to the primary completion date, 1 Mar 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnosis of other neurological conditions
- Signs or symptoms of acute or uncontrolled cardiovascular, renal or metabolic disease or other conditions that make it unsafe to exercise
- Additional exclusion criteria for functional electrical stimulation (FES) cycling exercise are cardiac demand pacemakers, implanted defibrillators, unhealed fractures, pregnancy, epilepsy, autonomic dysreflexia, and acute infections
Other
- Relapse within 30 days
- Currently engaging in regular aerobic exercise (≥ 2 sessions/week for ≥ 12 weeks)
Who the study is looking for
- ≥18 years of age
- Self-reported diagnosis of MS
- Expanded Disability Status Score ≥ 7.0
- Stable course of disease-modifying therapy over past six months
- Physician approval for exercise participation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.