NCT07548073Completed
Effect of Scene-Based Training on Cognitive Function in Patients With Alzheimer's Disease
Effect of Scenario-Based Reenactment Training on Orientation Impairment in Patients With Mild to Moderate Alzheimer' s Disease
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, including impairments in orientation, memory, and daily functioning. Orientation dysfunction, involving difficulties in recognizing time, place, and person, is a common and clinically significant feature in patients with mild to moderate AD. This study aims to evaluate the effectiveness of a scenario-based reenactment training program in improving cognitive function and orientation ability in patients with mild to moderate Alzheimer's disease. The intervention is based on patients' real-life experiences and uses personalized visual materials (e.g., photos and videos) to reconstruct familiar scenarios, thereby enhancing cognitive stimulation and environmental recognition. In this prospective controlled study, participants will be assigned to either a scenario-based training group or a usual care group. The intervention group will receive structured training sessions three times per week for 3 months, followed by a 6-month follow-up period. The control group will receive standard care without structured cognitive training. The primary outcome is global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes include orientation function, depressive symptoms, anxiety levels, quality of life, and intervention feasibility. This study aims to provide evidence for a practical, non-pharmacological intervention to improve cognitive and functional outcomes in patients with Alzheimer's disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 126 (actual)
- First submitted
- 14 Apr 2026
- Start date
- 1 Jan 2024
- Primary completion date
- 30 Dec 2024
- Lead sponsor
- Zhejiang Provincial Tongde Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT07548073
What you commit to
- Study type: Interventional
- Participants enrolled: 126
- From 1 Jan 2024 to the primary completion date, 30 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe psychiatric disorders (e.g., severe depression, schizophrenia)
- Severe cardiovascular, cerebrovascular, or other systemic diseases affecting participation
- History of neurological disorders other than Alzheimer's disease (e.g., Parkinson's disease, stroke with major deficits)
- Severe sensory impairment (vision or hearing) that interferes with intervention or assessment
Other
- Inability to complete study procedures or comply with follow-up
- Participation in other interventional clinical trials within the past 3 months
Who the study is looking for
- Age ≥ 60 years
- Diagnosis of mild to moderate Alzheimer's disease according to DSM-5 criteria
- Ability to communicate and complete cognitive assessments
- Stable caregiver available to assist with intervention and follow-up
- Visual and auditory function adequate to participate in assessments (with or without correction)
- Willingness to participate and provide informed consent (by patient or legal guardian)
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tongde Hospital of Zhejiang Province Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.