NCT07549633Not yet recruiting
Application of a Fasting-mimicking Diet in Obese Patients With Periodontitis Stage III-IV
Source: ClinicalTrials.gov · Last updated 24 Apr 2026
Brief summary (registry, in English)
This study will evaluate whether a fasting-mimicking diet (FMD) can improve the systemic and periodontal response to non-surgical periodontal treatment in obese adults with severe periodontitis. Periodontitis is a serious inflammatory disease that damages the tissues supporting the teeth and may also contribute to inflammation elsewhere in the body. Obesity is also associated with increased systemic inflammation, which may worsen periodontal disease and affect treatment outcomes. In this pilot randomized cross-over clinical trial, eligible participants will receive full-mouth non-surgical periodontal therapy and will be assigned either to an FMD group or to a control group continuing their usual diet. The FMD will be administered in three 5-day cycles around the periodontal treatment period. After a wash-out period, the groups will switch interventions. The study will assess whether FMD can reduce systemic inflammation, measured primarily by serum C-reactive protein (CRP), and improve periodontal healing after treatment. Additional outcomes include clinical periodontal measurements, inflammatory markers in gingival crevicular fluid, and changes in oral and gut microbiota. Findings from this study will help determine the feasibility of this dietary approach and provide preliminary data for a larger clinical trial.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 10 Apr 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- Akdeniz University
- Diseases
- Obesity
- NCT number
- NCT07549633
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Jun 2026 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking medications including systemic anti-inflammatory medication within 3 months of the study,
- Denture wearer/presence of dental implants,
Other illness
- Significant food allergies and/or special dietary requirements which would make the subject unable to consume the food provided.
Other
- Current smokers,
- Pregnant women,
- Patients drinking more than 20 units of alcohol weekly,
- Periodontal treatment and/or systemic antibiotics intake within preceding 3 months
Who the study is looking for
- 18-70-year-old patients,
- Severe Periodontitis (Stages III-IV),
- Systemically healthy,
- Overweight (body mass index - BMI \> 30 kg/m2),
- Absence of hopeless teeth, acute dental conditions, endo-perio lesions and necrotising periodontal diseases,
- Minimum of 20 teeth present.
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Akdeniz University Faculty of Dentistry Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.