NCT07550010Recruiting
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
Evaluation of Digital Cytology for the Triage of HPV-positive Women in a Same-day "Test-triage-treat" Cervical Cancer Screening Strategy in Cameroon
Source: ClinicalTrials.gov · Last updated 24 Apr 2026
Brief summary (registry, in English)
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon. Women aged 30-49 years (or 25-49 years if HIV-positive) will undergo primary HPV testing using the GeneXpert system. HPV-positive women will be managed according to an extended HPV genotyping-based algorithm, including immediate treatment, telecytology triage, or follow-up. Histological assessment serves as the reference standard for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Secondary objectives include evaluation of AI-assisted telecytology and visual inspection with acetic acid (VIA), as well as the acceptability of screening and treatment strategies among women and healthcare providers. The study aims to generate evidence to support scalable, WHO-recommended test-triage-treat approaches in low-resource settings
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1800 (estimated)
- First submitted
- 17 Apr 2026
- Start date
- 8 Sept 2025
- Primary completion date
- 8 Sept 2026
- Lead sponsor
- University Hospital, Geneva
- Diseases
- Cervical cancer
- NCT number
- NCT07550010
What you commit to
- Study type: Interventional
- Planned participants: 1800
- From 8 Sept 2025 to the primary completion date, 8 Sept 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous hysterectomy
Other illness
- Known cervical cancer
- Symptoms of cervical cancer (e.g. metrorrhagia, known pelvic mass)
- Conditions that can interfere with visualization of the cervix
- Severe pre-existing medical conditions (e.g. advanced cancer, terminal renal failure)
Other
- Pregnancy at the time of screening
- Women who are not able to comply with the study protocol.
Who the study is looking for
- HIV-negative women aged 30-49 and HIV-positive women aged 25-49 years old
- Ability to understand study procedures and accepting voluntarily to participate by signing an informed consent form (ICF).
Age in the registry: 25 years to 50 years · Sex: Female · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yaoundé University Teaching Hospital (CHU) Coordinator of this site? Confirm its status | Yaoundé | Cameroon | Recruiting |
| Centre Hospitalier Universitaire de Yaoundé Coordinator of this site? Confirm its status | Yaoundé | Cameroon | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.