NCT07550790Recruiting
Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
Contrast-Induced Acute Kidney Injury in Acute Heart Failure With Renal Dysfunction: The Kidney Protection Strategies Evaluation in Acute Heart Failure (K-PROSE)
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75 mL/min/1.73 m²). Patients requiring contrast-enhanced CT imaging are randomized to either standard intravenous saline hydration or a furosemide-based decongestion strategy. Renal function is assessed using serial measurements of creatinine and cystatin C, before and after contrast exposure. By comparing renal outcomes, congestion status, and safety profiles, this study aims to determine whether a decongestion-focused approach provides superior renal protection compared with conventional hydration in high-risk acute heart failure patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 190 (estimated)
- First submitted
- 19 Feb 2026
- Start date
- 1 Jul 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Jin Joo Park
- Diseases
- Heart failure
- NCT number
- NCT07550790
What you commit to
- Study type: Interventional
- Planned participants: 190
- From 1 Jul 2026 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Requirement for vasopressor therapy
- Requirement for renal replacement therapy (dialysis)
Other illness
- Known allergy or hypersensitivity to furosemide
- Ongoing acute coronary syndrome
- Any condition deemed by the investigator to make participation in the study inappropriate
Lab values
- Hyperkalemia (serum potassium \>5.5 mmol/L)
- Uncorrected volume depletion or hyponatremia (serum sodium \<130 mmol/L)
Other
- Pregnant or breastfeeding women, or women of childbearing potential without a negative pregnancy test
Who the study is looking for
- Adults aged 20 years or older
- Emergency department visit/hospitalization for acute heart failure with clinical evidence of congestion
- Planned contrast-enhanced computed tomography during the index hospitalization
- Baseline renal dysfunction defined as an estimated glomerular filtration rate (eGFR) of 30-75 mL/min/1.73 m²
Age in the registry: 20 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Seoul National University Bundang Hospital Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.