NCT07555977Recruiting
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
Super Large Bore Catheter Aspiration Versus Stent Retriever Thrombectomy as First Line Technique for Anterior Circulation Large Vessel Occlusion in Acute Ischemic Stroke
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel occlusion in acute ischemic stroke. Eligible patients with acute ischemic stroke due to internal carotid artery intracranial segment and/or middle cerebral artery M1 occlusion will be randomized 1:1 to receive either aspiration using a super large bore catheter (inner diameter ≥0.080 inch) or stent retriever thrombectomy (allowing balloon guiding catheters or intermediate catheters with inner diameter \<0.080 inch). The primary outcome is the ordinal modified Rankin Scale score at 90 days post-procedure. Key secondary outcomes include the proportion of patients with mRS 0-2 at 90 days, change in NIHSS at 24 hours and 7 days, and various angiographic and safety endpoints. The trial plans to enroll 708 patients across approximately 30 centers in China. The total study duration is 24-36 months, with each patient participating for 3 months.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 708 (estimated)
- First submitted
- 15 Apr 2026
- Start date
- 17 Sept 2026
- Primary completion date
- 30 Dec 2027
- Lead sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- Diseases
- Stroke
- NCT number
- NCT07555977
What you commit to
- Study type: Interventional
- Planned participants: 708
- From 17 Sept 2026 to the primary completion date, 30 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous intracranial aneurysm or vascular malformation in the culprit vessel;
- Concurrent participation in another clinical drug or device study;
Other illness
- Imaging shows acute or subacute intracranial hemorrhage (excluding microbleeds);
- Cerebral embolism caused by infection or bacterial endocarditis;
- Presence of a life-threatening illness within 6 months that would prevent 3-month follow-up;
- Pregnancy, psychiatric illness, severe hepatic or renal insufficiency, severe heart failure;
- Systemic infection;
- Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation in this study.
Other
- Imaging indicates an intracranial tumor (excluding meningiomas \<2 cm in diameter) or mass effect caused by a tumor, such as midline shift;
- The culprit vessel lesion is considered to be chronic atherosclerotic stenosis and occlusion;
- Pre-procedure imaging suggests that the lesion is due to dissection;
- Metastatic tumor;
Who the study is looking for
- Age ≥ 18 years;
- Clinically diagnosed with acute ischemic stroke, and pre-procedure imaging confirms that the culprit vessel is occlusion of the intracranial segment of the internal carotid artery and/or the middle cerebral artery M1 segment;
- Pre-stroke modified Rankin Scale (mRS) score of 0-1;
- Baseline National Institutes of Health Stroke Scale (NIHSS) score ≥ 6;
- Alberta Stroke Program Early CT Score (ASPECTS) ≥ 3;
- Time from symptom onset to initiation of endovascular treatment (arterial puncture) \< 24 hours; symptom onset time is defined as the "last known well" time;
- Intravenous thrombolysis and/or mechanical thrombectomy are performed according to local guidelines, and intravenous thrombolysis does not delay mechanical thrombectomy;
- Written informed consent is obtained from the patient or a family member.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.