NCT07558265Recruiting
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in which blood oxygen levels are dangerously low and require urgent treatment. This study compares two commonly used non-invasive respiratory support strategies to evaluate their effectiveness and safety, based on important patient outcomes during hospitalization, including survival, the need for invasive mechanical ventilation, and the duration of respiratory support. Participants will be randomly assigned (with an equal chance) to receive one of the following treatments: * Non-Invasive Positive Pressure Ventilation (NIPPV): Oxygen delivered under pressure through a face mask. * High-Flow Nasal Oxygen (HFNO): Oxygen delivered at high-flow through a specially designed nasal cannula placed in the nostrils. Researchers will compare the two treatment strategies using a hierarchical assessment of major pulmonary outcomes, including: * Hospital survival * Days on mechanical ventilation * Duration of non-invasive respiratory support As part of the study, researchers will collect: * Blood and urine samples * Physiologic measurements (such as chest movement measured through sensors placed on the skin) * Information from participants' medical records
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 500 (estimated)
- First submitted
- 23 Apr 2026
- Start date
- 18 Aug 2026
- Primary completion date
- 31 Aug 2031
- Lead sponsor
- Ohio State University
- Diseases
- Heart failure, COPD
- NCT number
- NCT07558265
What you commit to
- Study type: Interventional
- Planned participants: 500
- From 18 Aug 2026 to the primary completion date, 31 Aug 2031
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous enrollment in WINDSURFER
Other illness
- Cardiac arrest
- Home use of non-invasive positive-pressure ventilation for respiratory support of a medical condition other than sleep apnea
- History of advanced chronic obstructive pulmonary disease
- History of advanced heart failure
Other
- Urgent need for intubation
- Respiratory arrest
- Patient not located in the ED
- Craniofacial anatomic features that prohibit either Non-Invasive Positive Pressure Ventilation (NIPPV) or High Flow Nasal Oxygen (HFNO) interface
- Tracheostomy or laryngectomy stoma
- Hemodynamic instability requiring \>0.2mcg/kg/min of norepinepherine (or equivalent) to maintain mean arterial pressure \>65mmHg
- Pre-existing "do not resuscitate" or "do not intubate" order
- Transferred from another Emergency Department
- Presence of opt-out identification
- Prisoner
- Known or apparent pregnant
- A patient-specific contraindication makes one assigned study intervention unsafe
Who the study is looking for
- Age ≥18 years
- Presenting to the Emergency Department (ED) with Acute Hypoxemic Respiratory failure (AHRF), defined as:
- \[(respiratory rate ≥25 breaths/min) AND (requiring ≥6 L/min of oxygen required to maintain SpO2 ≥90%), OR SpO2:FiO2 ratio\<250\] OR
- Arrival at ED on prehospital Non-Invasive Respiratory Support (NIRS).
- Clinical need for NIRS
- Randomization ≤2 hours after identification of need for NIRS
- Randomization ≤6 hours of ED arrival
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Medical Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| OSU Wexner Medical Center Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Ohio State East Hospital Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Intermountain Medical Center Coordinator of this site? Confirm its status | Murray | United States | Recruiting |
| Harborview Medical Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Banner University Medical Center - Tucson Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.