NCT07558629Active, not recruiting
SH-SDU Shandong Endometriosis Reproductive Cohort
SH-SDU Shandong Endometriosis Reproductive Cohort: A Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
Endometriosis (EMs) is a chronic, estrogen-dependent, multi-systemic disease that affects approximately 190 million women worldwide. EMs can increase the risk of miscarriage, and even mild EMs can negatively affect fertilization and implantation rates. Some meta-analyses have reported that EMs increases the risk of adverse obstetric outcomes, such as preterm birth and cesarean section, and also increases the risk of neonatal hospitalization. In addition to affecting pregnancy outcomes in women of reproductive age, EMs has significant social and psychological impacts on women of all ages in multiple areas of life, and can further affect the entire family, leading to substantial economic burdens and reduced quality of life. Finally, due to the increased incidence of the disease in the offspring of EMs patients, long-term follow-up is also a key aspect of disease management. To improve clinical practice and enhance fertility in EMs patients, more evidence is needed to meet the key priorities of future research. Integrated analysis of comprehensive case resources and clinical data can provide a reliable research foundation for future personalized diagnosis and treatment. High-quality and traceable large biobanks are a crucial resource for exploring pathogenic mechanisms. Prospective cohort studies conducted on this basis are expected to investigate the impact of the disease on patient clinical outcomes and further explore the disease's pathogenesis, aiming to identify physiological pathways influenced by the epigenome, transcriptome, proteome, and metabolome. ...
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 5000 (estimated)
- First submitted
- 3 Feb 2026
- Start date
- 14 Oct 2025
- Primary completion date
- 31 Jan 2036
- Lead sponsor
- The Second Hospital of Shandong University
- Diseases
- Endometriosis
- NCT number
- NCT07558629
What you commit to
- Study type: Observational
- Planned participants: 5000
- From 14 Oct 2025 to the primary completion date, 31 Jan 2036
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The patient previously underwent unilateral/bilateral oophorectomy due to the disease;
- The patient was previously diagnosed with a tumor-related disease;
Other illness
- The patient suffers from a severe uterine leiomyoma or other serious diseases;
- The patients with immune disorders or metabolic diseases;
Other
- The patient undergoes egg cell donation;
- The patient underwent pre-implantation genetic diagnosis.
Who the study is looking for
- Patients with endometriosis and non-endometriosis who are scheduled to undergo in vitro fertilization/ intracytoplasmic sperm injection treatment at our hospital;
- Womens' age \<38 year;
- Patients diagnosed with endometriosis through surgery, ultrasound or magnetic resonance imaging.
Age in the registry: 20 years to 37 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Hospital of Shandong University Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.