NCT07560189Active, not recruiting
IPF Longitudinal Natural History Study
Natural History and Temporal Dynamics of Idiopathic Pulmonary Fibrosis: A Longitudinal Cohort Study With Structured Disease Stratification
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This is a longitudinal observational cohort study of patients with idiopathic pulmonary fibrosis (IPF) conducted within the Assiut University IPF Research Program between 2022 and 2026. The study aims to characterize the natural history, temporal disease dynamics, event patterns, and clinical outcomes of IPF over a two-year follow-up period. Primary analyses focus on disease progression, acute exacerbation, hospitalization, mortality, and final clinical state. Secondary analyses include prespecified evaluation of the Inflammatory Burnout Index (IBI; Zenodo DOI: 10.5281/zenodo.18843181) and the Severity-Phenotype-Dynamics integration framework (SPD; Zenodo DOI: 10.5281/zenodo.18843362) as observational analytical frameworks for disease activity and multidimensional disease characterization. These frameworks are applied for research stratification only and do not influence treatment allocation, clinical management, or follow-up decisions.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1423 (actual)
- First submitted
- 24 Apr 2026
- Start date
- 1 Apr 2022
- Primary completion date
- 1 Nov 2026
- Lead sponsor
- Assiut University
- Diseases
- Idiopathic pulmonary fibrosis
- NCT number
- NCT07560189
What you commit to
- Study type: Observational
- Participants enrolled: 1423
- From 1 Apr 2022 to the primary completion date, 1 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Long-term systemic immunosuppressive therapy not aligned with standard IPF management
Other illness
- Interstitial lung disease other than idiopathic pulmonary fibrosis
- End-stage disease at baseline requiring invasive mechanical ventilation or terminal care
- Active malignancy or severe comorbidity expected to dominate short-term prognosis
Other
- Alternative diagnosis inconsistent with IPF based on clinical or radiological evaluation
- Incomplete baseline data preventing cohort classification
- Refusal to participate or inability to complete follow-up
Who the study is looking for
- Adults aged ≥18 years.
- Diagnosis of idiopathic pulmonary fibrosis based on clinical and radiological assessment according to standard guidelines.
- Availability of baseline clinical, functional, and radiological evaluation.
- Enrollment within the Assiut University IPF Research Program.
- Ability to undergo longitudinal follow-up and outcome assessment.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty Of Medicine - Assiut University Hospitals - Assiut - Egypt Coordinator of this site? Confirm its status | Asyut | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.