NCT07561840Recruiting
Exercise Training After Upper Gastrointestinal Cancer Surgery
Exercise and Cardiorespiratory Fitness Improvement Through Supervised Training in Upper Gastrointestinal Cancer Surgery Patients (EXCITING-UGI)
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
This randomized controlled trial aims to determine the optimal exercise intensity for improving postoperative recovery in patients with upper gastrointestinal cancer. Participants who have undergone curative surgery will be randomly assigned to high-intensity interval training (HIIT), low-intensity continuous training (LICT), or usual care. The exercise interventions will be performed under supervision three times per week for eight weeks. The primary outcome is peak oxygen uptake (VO₂peak), assessed using cardiopulmonary exercise testing. Secondary outcomes include physical function, body composition, patient-reported outcomes, and biological and mechanistic markers such as inflammatory biomarkers, muscle-related factors, and gut microbiota. This study will also explore potential mechanisms underlying exercise-induced adaptations and their association with clinical outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 171 (estimated)
- First submitted
- 24 Apr 2026
- Start date
- 15 May 2026
- Primary completion date
- Nov 2029
- Lead sponsor
- Kansai Medical University
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT07561840
What you commit to
- Study type: Interventional
- Planned participants: 171
- From 15 May 2026 to the primary completion date, Nov 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Communication difficulties
- Poor general status
- Undergone combined laryngopharyngectomy
- Unsuitable for evaluation or exercise intervention
- Unsuitable for the study as determined by the primary physician
Who the study is looking for
- Age ≥ 18 years
- Diagnosed with esophageal or gastric cancer
- Received curative surgery
- 6 ± 2 weeks after surgery
- Ability to provide written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kansai Medical University Coordinator of this site? Confirm its status | Hirakata | Japan | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.