NCT07565610Not yet recruiting
Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity. The main questions it aims to answer are: Does fat inside the heart muscle decrease after weight loss surgery? Does heart relaxation (diastolic function) improve after surgery? Are changes in heart fat linked to changes in weight, body fat, and blood markers? Participants who are already planning to have weight loss surgery will take part in this study. Participants will: Have a heart CT scan to measure fat in the heart muscle before surgery and about 6 months after surgery Have an ultrasound of the heart (echocardiogram) to check how the heart fills and relaxes Have body composition testing to measure fat and muscle Have blood tests, including routine tests and additional markers related to heart function and metabolism Researchers will compare each participant's results before and after surgery to see if heart fat decreases and if heart function and blood markers improve.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 15 Apr 2026
- Start date
- 10 Oct 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- Itshak Amsalem
- Diseases
- Heart failure, Obesity
- NCT number
- NCT07565610
What you commit to
- Study type: Observational
- Planned participants: 150
- From 10 Oct 2026 to the primary completion date, 31 May 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of intracardiac or cardiac-related foreign material that may interfere with imaging (e.g., prosthetic valves, pacemakers, prior transcatheter devices)
Other illness
- Significant valvular heart disease
- Contraindication to cardiac CT (e.g., severe renal dysfunction, contrast allergy)
Lab values
- Left ventricular ejection fraction (LVEF) \<50%
Other
- Known cardiomyopathies, including sarcoidosis, amyloidosis, or myocarditis
Who the study is looking for
- Adults aged 18 years or older
- Scheduled to undergo bariatric surgery for standard clinical indications
- Left ventricular ejection fraction (LVEF) ≥50%
- Able to undergo cardiac computed tomography (CT)
Age in the registry: 18 years to - · Sex: All
This page is information, not medical advice. Discuss any trial with your doctor.