NCT07568054Not yet recruiting
Neural Correlates of Suicidal Behavior in Youth
Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this population, and current clinical approaches often fail to accurately predict or prevent suicidal behavior. This study seeks to identify objective neurobiological markers associated with suicide risk and treatment response. Participants will be divided into three groups: (1) high-risk individuals recently hospitalized following a suicide attempt, (2) medium-risk individuals with chronic suicidal ideation but no attempts, and (3) low-risk healthy controls. All participants will undergo advanced neuroimaging, including magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with comprehensive psychiatric assessments. The study focuses on brain regions and networks implicated in suicidality, including the anterior cingulate cortex and salience network, as well as neurochemical markers such as glutamate. It also examines electrophysiological activity and functional connectivity patterns associated with suicidal thoughts and behaviors. High-risk participants will receive an evidence-based psychotherapy called the Collaborative Assessment and Management of Suicidality (CAMS). This therapeutic approach emphasizes collaboration between patient and clinician to identify and address the underlying drivers of suicidal thoughts, with a focus on increasing hope and reducing psychological distress. Neuroimaging and clinical assessments will be repeated after completion of CAMS to evaluate treatment-related changes. The study's primary goals are to: * Identify neural and electrophysiological correlates of suicide risk. * Distinguish biological differences between individuals with suicidal ideation and those who have attempted suicide. * Determine how CAMS therapy affects brain function and neurochemistry. By integrating clinical and neurobiological data, this research aims to improve understanding of suicidality, enhance risk prediction, and inform more effective, personalized interventions for at-risk youth.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 10 Apr 2026
- Start date
- 30 Oct 2026
- Primary completion date
- 1 Sept 2031
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Depression
- NCT number
- NCT07568054
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 30 Oct 2026 to the primary completion date, 1 Sept 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for the management of ADHD will not be excluded)
- Subjects with recent bone, tendon, spine or joint surgery
- Subjects with recent metallic dental implants
Other illness
- Subjects with known history of Autism Spectrum Disorder; non-verbal patients
- Subjects with Schizophrenia or history of any type of psychosis including mood related psychosis and brief reactive psychosis
- Subjects with a history of moderate or severe substance or alcohol use per DSM-5 criteria in the past 6 months
Other
- Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education classes full time)
- Subjects who are currently pregnant or breastfeeding
- Subjects in custody of Children's Services
- Subjects weighing less than 30 kg or more than 200 kg
Who the study is looking for
- Subjects must be 14-24 years old
- Subjects must be:
- High Risk Subjects: Psychiatrically admitted due to a suicide attempt or history of 2 previous suicide attempts
- Medium Risk Subjects: Suicide ideation for the past year with no suicide attempt
- Minimal Risk Subjects: No previous history of suicidal ideation or behavior, not taking any psychiatric history or medication, and no family history of suicide
- Subjects must have the ability to understand and the willingness to sign a written informed consent/assent document
- Subjects must be English speaking
Age in the registry: 14 years to 24 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.