NCT07571876Not yet recruiting
Ultrasound Prediction of Esophageal Variceal Bleeding Risk
Splenic Size and Portal Vein Diameter on Ultrasound in Predicting Esophageal Variceal Bleeding Risk
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
This prospective observational study aims to evaluate the accuracy of using routine abdominal ultrasound to predict the risk of esophageal variceal bleeding in adult patients with liver cirrhosis. Esophageal variceal bleeding is a serious complication of chronic liver disease. While upper gastrointestinal endoscopy is the current standard for diagnosing and grading these varices, it is an invasive procedure. In this study, researchers will use ultrasound to measure the patient's spleen size and portal vein diameter. These non-invasive measurements will then be compared to the results of a standard upper endoscopy performed within 48 to 72 hours. The goal is to determine if these simple ultrasound measurements can reliably predict the presence, grade, and bleeding risk of esophageal varices, which could potentially reduce the need for routine invasive endoscopic screenings in the future.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 165 (estimated)
- First submitted
- 4 Mar 2026
- Start date
- Apr 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- Assiut University
- Diseases
- High blood pressure
- NCT number
- NCT07571876
What you commit to
- Study type: Observational
- Planned participants: 165
- From Apr 2026 to the primary completion date, Apr 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of endoscopic variceal band ligation or sclerotherapy
- Prior surgical portosystemic shunt procedures or transjugular intrahepatic portosystemic shunt (TIPS)
- Previous splenectomy
- Patients receiving beta-blockers for variceal bleeding prophylaxis
Other illness
- Hepatocellular carcinoma with portal vein thrombosis
Other
- Poor quality ultrasound images due to obesity or ascites
- Refusal to participate in the study
Who the study is looking for
- Adult patients (age ≥18 years) with chronic liver disease and clinical/laboratory/radiological evidence of liver cirrhosis
- Both compensated and decompensated cirrhosis (Child-Pugh classes A, B, and C)
- Patients scheduled for upper gastrointestinal endoscopy
- Patients who provide informed consent
Age in the registry: 18 years to - · Sex: All
This page is information, not medical advice. Discuss any trial with your doctor.