NCT07571889Recruiting
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 21 Nov 2025
- Start date
- 3 Mar 2026
- Primary completion date
- Jan 2027
- Lead sponsor
- Association of Migraine Disorders
- Diseases
- Migraine
- NCT number
- NCT07571889
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 3 Mar 2026 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis
- Known allergy/hypersensitivity to lidocaine or amide anesthetics
Age
- Aged \< 18 years
Other
- Not able to provide informed consent
- Pregnancy/lactation
- Inability to tolerate intranasal nasal cotton pledgets
- Significant nasal pathology at placement site
Who the study is looking for
- Aged ≥18 years
- Any gender
- Able to provide informed consent
- Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month)
- Scheduled for modified PREEMPT injections at the clinical site
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Otolaryngology Coordinator of this site? Confirm its status | East Providence | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.