NCT07573046Not yet recruiting
Validation Study of the ExéSem Battery Designed to Differentiate the Contribution of Executive Functions in Semantic Disorders
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
This protocol describes a study aimed at evaluating the psychometric properties of the ExéSem battery, developed to differentiate semantic deficits from executive semantic impairments in patients with post-lesional or neurodegenerative anomia. Currently available tools do not allow a straightforward distinction between these deficits, limiting diagnostic accuracy and clinical management. The ExéSem battery was developed through a collaboration between Hospices Civils de Lyon, the University of Mons, and Laval University to address this gap. The battery includes three main tasks: (1) a dual task combining semantic judgment and semantic matching using identical items, (2) a word-picture matching task, and (3) a rapid naming task. Each task is designed to manipulate the level of executive control required to access semantic representations. This allows the identification of whether performance declines under increased executive demand, thereby distinguishing executive-related semantic impairments.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 140 (estimated)
- First submitted
- 23 Apr 2026
- Start date
- 9 Sept 2026
- Primary completion date
- 31 Aug 2029
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Alzheimer disease
- NCT number
- NCT07573046
What you commit to
- Study type: Observational
- Planned participants: 140
- From 9 Sept 2026 to the primary completion date, 31 Aug 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants previously diagnosed with cognitive impairment.
Other illness
- Severe, progressive, or unstable medical conditions that may interfere with assessment variables (epilepsy, acute psychiatric or psychotic disorders, visual hallucinations, acute infection);
- Specifically for participants without cognitive impairment:
- Specifically for participants with cognitive impairment:
Other
- \- For all participants:
- Substance use that may affect cognitive performance;
- Deafness or blindness that may compromise the participant's assessment or participation in tasks and scales;
- Participants under guardianship, curatorship, or legal protection;
- Pregnant, postpartum, or breastfeeding women.
- Severe behavioral and psychological symptoms that prevent task completion, as determined by the investigator.
Who the study is looking for
- \- Participants without cognitive impairment
- Participant aged 50 to 90 years (inclusive);
- Participant whose native language is French
- Participant affiliated with or entitled to a social security scheme;
- Participants who have been informed and have not objected.
- Participants with cognitive impairment
- Participant aged 50 to 90 years (inclusive);
- Participant whose native language is French
- Participant receiving memory care with a diagnosis of Alzheimer's disease, at the stage of minor or major neurocognitive impairment, according to the 2011 NIA-AA criteria (McKahn et al., 2011), or with a diagnosis of vascular neurocognitive impairment according to the VasCog-2-WSO diagnostic criteria (Sachdev et al., 2025), or with a diagnosis of primary progressive aphasia with semantic variant (Gorno-Tempini et al., 2011).
- Mini-Mental State Examination (MMSE) score ≥ 20/30, within the 6 months preceding enrollment;
- Participants affiliated with or entitled to a social security scheme;
- Participants who have been informed and have not objected.
Age in the registry: 50 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital des CHARPENNES ( Hospices Civils de Lyon) Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.