NCT07573501Not yet recruiting
Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with cognitive impairment after stroke, and to evaluate the safety of this protocol. The main purpose is to answer the following question: Can dual-site cross-frequency coupled tACS in the frontal parietal region improve the performance of working memory and cognitive-motor dual tasks in stroke patients? What is its mechanism of action? Researchers will compare the effects of real cross-frequency coupled stimuli and sham stimuli to see if the real stimuli can bring better results to patients. Participants will receive 40 minutes of real or sham electrical stimulation once a day for 5 consecutive days. Clinical evaluations (cognitive scales) and fNIRS were conducted respectively before and after stimulation to record the relevant brain activities at rest and during cognitive tasks
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 22 Apr 2026
- Start date
- 1 May 2026
- Primary completion date
- 1 May 2027
- Lead sponsor
- Ke Dong, MD
- Diseases
- Stroke
- NCT number
- NCT07573501
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 1 May 2026 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving non-invasive brain stimulation treatment;
Other illness
- History of epilepsy, mental illness,or other neurological or mental disorders;
Other
- Lesions involving the left DLPFC brain regions;
- Any contraindications for transcranial electrical stimulation.
Who the study is looking for
- Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
- Age ranging from 30 to 80 years old;
- Native language is Mandarin or Cantonese;
- Right-handed;
- Diagnosed with PSCI by the MoCA scale;
- Able to cooperate in completing the speech repetition test;
- Normal hearing.
Age in the registry: 30 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.