NCT07575399RecruitingPhase 3
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
A Phase 3, Open-label Trial to Evaluate the Efficacy, Safety and Tolerability of Switching From the Glucagon-like Peptide-1 Receptor Agonists to Maridebart Cafraglutide in Adult Participants With Obesity or Overweight
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 4 May 2026
- Start date
- 11 May 2026
- Primary completion date
- 3 Jan 2028
- Lead sponsor
- Amgen
- Diseases
- Obesity
- NCT number
- NCT07575399
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 300
- From 11 May 2026 to the primary completion date, 3 Jan 2028
- 54 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous or planned surgical, endoscopic or device-based treatment for obesity.
- Previous participation in a Maridebart Cafraglutide trial.
Other illness
- Obesity induced by other endocrine disorders (ex: Cushing's syndrome).
- History of malignancy.
- Type 1/Type 2 diabetes mellitus (DM).
- Family or personal history of medullary thyroid cancer.
Who the study is looking for
- Body Mass Index (BMI) ≥ 25 at screening.
- Weight loss of ≥ 10% on weekly GLP-1 RA.
- Stable body weight.
- Stable dose of GLP-1RA.
- Stable gastrointestinal (GI) tolerability.
- Contraception for females.
- Willingness to follow trial procedures for the duration of the trial.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (54)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Puerto Rico Medical Research Inc. Coordinator of this site? Confirm its status | Ponce | Puerto Rico | Recruiting |
| Pinnacle Clinical Research Georgetown Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Pennington Biomedical Research Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
| Heritage Valley Multispecialty Group, Inc Coordinator of this site? Confirm its status | Beaver | United States | Recruiting |
| East Coast Institute for Research Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Arizona Clinical Trials Coordinator of this site? Confirm its status | Chandler | United States | Recruiting |
| Epic Medical Research - Oklahoma Coordinator of this site? Confirm its status | Chickasha | United States | Recruiting |
| Peninsula Research Associates Coordinator of this site? Confirm its status | Chula Vista | United States | Recruiting |
| Epic Medical Research - DeSoto Coordinator of this site? Confirm its status | DeSoto | United States | Recruiting |
| Altoona Center For Clinical Research Coordinator of this site? Confirm its status | Duncansville | United States | Recruiting |
| South Texas Research Institute Coordinator of this site? Confirm its status | Edinburg | United States | Terminated |
| University of Florida Department of Medicine Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
| AGA Clinical Trials Coordinator of this site? Confirm its status | Hialeah | United States | Recruiting |
| Research Physicians Network, LLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Biopharma Informatic, LLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| NSC Research Coordinator of this site? Confirm its status | Johns Creek | United States | Recruiting |
| Mel A. Ona, M.D., Incorporated Coordinator of this site? Confirm its status | Kapolei | United States | Recruiting |
| Excel Clinical Research Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| South Florida Clinical Research Coordinator of this site? Confirm its status | Margate | United States | Recruiting |
| Texas Institute of Cardiology Coordinator of this site? Confirm its status | McKinney | United States | Recruiting |
| Solaris Clinical Research Coordinator of this site? Confirm its status | Meridian | United States | Recruiting |
| Research Institute of South Florida Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Montana Medical Research Coordinator of this site? Confirm its status | Missoula | United States | Recruiting |
| Centricity Research Morehead City Specialty Coordinator of this site? Confirm its status | Morehead City | United States | Recruiting |
| Adult Medicine of Lake County Coordinator of this site? Confirm its status | Mt. Dora | United States | Recruiting |
| Icahn School of Medicine at Mount Sinai Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| North Hills Medical Research Coordinator of this site? Confirm its status | North Richland Hills | United States | Recruiting |
| Lynn Health Science Institute Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| Clinical Neuroscience Solutions Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Florida Institute for Clinical Research Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Desert Oasis Healthcare Medical Group Coordinator of this site? Confirm its status | Palm Springs | United States | Recruiting |
| Cahaba Research, Inc. Coordinator of this site? Confirm its status | Pelham | United States | Recruiting |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Recruiting |
| Accellacare of Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Recruiting |
| Eastside Research Associates Health Research Coordinator of this site? Confirm its status | Redmond | United States | Recruiting |
| Inland Empire Liver Foundation Coordinator of this site? Confirm its status | Rialto | United States | Recruiting |
| Sky Integrative Medical Center Coordinator of this site? Confirm its status | Ridgeland | United States | Recruiting |
| Rochester Clinical Research Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| American Research Corporation Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| Gastroenterology Clinic of San Antonio PA Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| VIP Trials Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| Apex Clinical Research Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| Southern California Clinical Research Coordinator of this site? Confirm its status | Santa Ana | United States | Recruiting |
| Endeavor Health Coordinator of this site? Confirm its status | Skokie | United States | Recruiting |
| Central Illinois Diabetes and Clinical Research, a Division of Prairie Education and Research Cooper Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Epic Medical Research - Sun City Coordinator of this site? Confirm its status | Sun City | United States | Recruiting |
| Clinical Research Institute of Arizona, LLC Coordinator of this site? Confirm its status | Sun City West | United States | Recruiting |
| Charter Research The Villages Coordinator of this site? Confirm its status | The Villages | United States | Recruiting |
| Northwest Houston Heart Center Coordinator of this site? Confirm its status | Tomball | United States | Recruiting |
| Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division Coordinator of this site? Confirm its status | Troy | United States | Recruiting |
| Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group Coordinator of this site? Confirm its status | Union City | United States | Recruiting |
| Accellacare Research of Wilmington Coordinator of this site? Confirm its status | Wilmington | United States | Recruiting |
| North Georgia Clinical Research Coordinator of this site? Confirm its status | Woodstock | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.