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NCT07575399RecruitingPhase 3

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

A Phase 3, Open-label Trial to Evaluate the Efficacy, Safety and Tolerability of Switching From the Glucagon-like Peptide-1 Receptor Agonists to Maridebart Cafraglutide in Adult Participants With Obesity or Overweight

Source: ClinicalTrials.gov · Last updated 23 Oct 2026

Brief summary (registry, in English)

Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
300 (estimated)
First submitted
4 May 2026
Start date
11 May 2026
Primary completion date
3 Jan 2028
Lead sponsor
Amgen
Diseases
Obesity
NCT number
NCT07575399

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 300
  • From 11 May 2026 to the primary completion date, 3 Jan 2028
  • 54 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous or planned surgical, endoscopic or device-based treatment for obesity.
  • Previous participation in a Maridebart Cafraglutide trial.

Other illness

  • Obesity induced by other endocrine disorders (ex: Cushing's syndrome).
  • History of malignancy.
  • Type 1/Type 2 diabetes mellitus (DM).
  • Family or personal history of medullary thyroid cancer.

Who the study is looking for

  • Body Mass Index (BMI) ≥ 25 at screening.
  • Weight loss of ≥ 10% on weekly GLP-1 RA.
  • Stable body weight.
  • Stable dose of GLP-1RA.
  • Stable gastrointestinal (GI) tolerability.
  • Contraception for females.
  • Willingness to follow trial procedures for the duration of the trial.

Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (54)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Puerto Rico Medical Research Inc.
Coordinator of this site? Confirm its status
PoncePuerto RicoRecruiting
Pinnacle Clinical Research Georgetown
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AustinUnited StatesRecruiting
Pennington Biomedical Research Center
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Baton RougeUnited StatesRecruiting
Heritage Valley Multispecialty Group, Inc
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BeaverUnited StatesRecruiting
East Coast Institute for Research
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CantonUnited StatesRecruiting
Arizona Clinical Trials
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ChandlerUnited StatesRecruiting
Epic Medical Research - Oklahoma
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ChickashaUnited StatesRecruiting
Peninsula Research Associates
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Chula VistaUnited StatesRecruiting
Epic Medical Research - DeSoto
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DeSotoUnited StatesRecruiting
Altoona Center For Clinical Research
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DuncansvilleUnited StatesRecruiting
South Texas Research Institute
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EdinburgUnited StatesTerminated
University of Florida Department of Medicine
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GainesvilleUnited StatesRecruiting
AGA Clinical Trials
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HialeahUnited StatesRecruiting
Research Physicians Network, LLC
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HoustonUnited StatesRecruiting
Biopharma Informatic, LLC
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HoustonUnited StatesRecruiting
NSC Research
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Johns CreekUnited StatesRecruiting
Mel A. Ona, M.D., Incorporated
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KapoleiUnited StatesRecruiting
Excel Clinical Research
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Las VegasUnited StatesRecruiting
South Florida Clinical Research
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MargateUnited StatesRecruiting
Texas Institute of Cardiology
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McKinneyUnited StatesRecruiting
Solaris Clinical Research
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MeridianUnited StatesRecruiting
Research Institute of South Florida
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MiamiUnited StatesRecruiting
New Horizon Research Center
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MiamiUnited StatesRecruiting
Montana Medical Research
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MissoulaUnited StatesRecruiting
Centricity Research Morehead City Specialty
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Morehead CityUnited StatesRecruiting
Adult Medicine of Lake County
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Mt. DoraUnited StatesRecruiting
Icahn School of Medicine at Mount Sinai
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New YorkUnited StatesRecruiting
North Hills Medical Research
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North Richland HillsUnited StatesRecruiting
Lynn Health Science Institute
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Oklahoma CityUnited StatesRecruiting
Clinical Neuroscience Solutions
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OrlandoUnited StatesRecruiting
Florida Institute for Clinical Research
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OrlandoUnited StatesRecruiting
Desert Oasis Healthcare Medical Group
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Palm SpringsUnited StatesRecruiting
Cahaba Research, Inc.
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PelhamUnited StatesRecruiting
Progressive Medical Research
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Port OrangeUnited StatesRecruiting
Accellacare of Raleigh
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RaleighUnited StatesRecruiting
Eastside Research Associates Health Research
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RedmondUnited StatesRecruiting
Inland Empire Liver Foundation
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RialtoUnited StatesRecruiting
Sky Integrative Medical Center
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RidgelandUnited StatesRecruiting
Rochester Clinical Research
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RochesterUnited StatesRecruiting
American Research Corporation
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San AntonioUnited StatesRecruiting
Gastroenterology Clinic of San Antonio PA
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San AntonioUnited StatesRecruiting
VIP Trials
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San AntonioUnited StatesRecruiting
Apex Clinical Research
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San DiegoUnited StatesRecruiting
Southern California Clinical Research
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Santa AnaUnited StatesRecruiting
Endeavor Health
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SkokieUnited StatesRecruiting
Central Illinois Diabetes and Clinical Research, a Division of Prairie Education and Research Cooper
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SpringfieldUnited StatesRecruiting
Epic Medical Research - Sun City
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Sun CityUnited StatesRecruiting
Clinical Research Institute of Arizona, LLC
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Sun City WestUnited StatesRecruiting
Charter Research The Villages
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The VillagesUnited StatesRecruiting
Northwest Houston Heart Center
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TomballUnited StatesRecruiting
Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
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TroyUnited StatesRecruiting
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group
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Union CityUnited StatesRecruiting
Accellacare Research of Wilmington
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WilmingtonUnited StatesRecruiting
North Georgia Clinical Research
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WoodstockUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.