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NCT07575932Active, not recruitingPhase 2

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity

A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE-RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)

Source: ClinicalTrials.gov · Last updated 13 Oct 2026

Brief summary (registry, in English)

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Status (registry)
Active, not recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
940 (actual)
First submitted
4 May 2026
Start date
11 May 2026
Primary completion date
4 Aug 2027
Lead sponsor
Pfizer
Diseases
Obesity
NCT number
NCT07575932

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 940
  • From 11 May 2026 to the primary completion date, 4 Aug 2027
  • 63 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Participants who are not eligible include those with diabetes mellitus, a body weight change of \>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.

Who the study is looking for

  • Eligible participants for this study include:
  • adults aged 18 years or older with
  • obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with
  • overweight (BMI of 27.0 kg/m2 to \<30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (63)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Aggarwal and Associates Limited
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BramptonCanadaUnknown status
Viable Clinical Research Corporation
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BridgewaterCanadaUnknown status
Ecogene-21
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ChicoutimiCanadaUnknown status
Centricity Research Etobicoke Endocrinology
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EtobicokeCanadaUnknown status
Milestone Research Inc.
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LondonCanadaUnknown status
Centricity Research Mirabel Multispecialty
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MirabelCanadaUnknown status
Recherche GCP Research
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MontrealCanadaUnknown status
Bluewater Clinical Research Group Inc.
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SarniaCanadaUnknown status
Centricity Research Toronto Manna Multispecialty
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TorontoCanadaUnknown status
Dr. Anil K. Gupta Medicine Professional Corporation
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TorontoCanadaUnknown status
Washington Center for Weight Management and Research
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ArlingtonUnited StatesUnknown status
Atlanta Diabetes Associates
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AtlantaUnited StatesUnknown status
Mercury Street Medical Group, PLLC
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ButteUnited StatesUnknown status
San Fernando Valley Health Institute
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Canoga ParkUnited StatesUnknown status
DelRicht Research
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CharlotteUnited StatesUnknown status
Cedar Health Research - Euless
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EulessUnited StatesUnknown status
Ark Clinical Research
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Fountain ValleyUnited StatesUnknown status
Paragon Rx Clinical
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Garden GroveUnited StatesUnknown status
Bioluminux Clinical Research
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HamiltonUnited StatesUnknown status
DelRicht Research
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HendersonvilleUnited StatesUnknown status
AGA Clinical Trials
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HialeahUnited StatesUnknown status
JCCT- Juno NW Houston
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HoustonUnited StatesUnknown status
Westside Center for Clinical Research
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JacksonvilleUnited StatesUnknown status
Activian Clinical Research
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KingwoodUnited StatesUnknown status
AB Clinical Trials
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Las VegasUnited StatesUnknown status
Alliance Clinical Research Las Vegas (Excel Clinical Research)
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Las VegasUnited StatesUnknown status
Palm Research Center
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Las VegasUnited StatesUnknown status
Johnson County Clinical Trials
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LenexaUnited StatesUnknown status
Torrance Clinical Research Institute, Inc.
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LomitaUnited StatesUnknown status
Ark Clinical Research
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Long BeachUnited StatesUnknown status
Collaborative Neuroscience Research, LLC
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Los AlamitosUnited StatesUnknown status
Patient First Clinical Trials (PFCTRIALS)
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LuthervilleUnited StatesUnknown status
Manassas Clinical Research Center
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ManassasUnited StatesUnknown status
DelRicht Research
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MandevilleUnited StatesUnknown status
New Horizon Research Center
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MiamiUnited StatesUnknown status
Paradigm Clinical Research - Modesto
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ModestoUnited StatesUnknown status
Monroe Biomedical Research
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MonroeUnited StatesUnknown status
Koch Family Medicine Clinical Research/Elite Research Network
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MortonUnited StatesUnknown status
TMA Headlands LLC (d/b/a Trial Management Associates)
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Myrtle BeachUnited StatesUnknown status
Bioluminux Clinical Research Illinois
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NapervilleUnited StatesUnknown status
Tekton Research, LLC.
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Oklahoma CityUnited StatesUnknown status
Charter Research
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OrlandoUnited StatesUnknown status
Preferred Primary Care Physicians
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PittsburghUnited StatesUnknown status
3A Research
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PlanoUnited StatesUnknown status
DelRicht Research
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PrairievilleUnited StatesUnknown status
DelRicht Research @ Zomnir Family Medicine
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ProsperUnited StatesUnknown status
Alpine Medical Group
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Salt Lake CityUnited StatesUnknown status
Wasatch Clinical Research, LLC
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Salt Lake CityUnited StatesUnknown status
Worldwide Clinical Trials
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San AntonioUnited StatesUnknown status
Tekton Research, LLC
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San AntonioUnited StatesUnknown status
Paradigm Clinical Research Centers, LLC
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San DiegoUnited StatesUnknown status
Consano Clinical Research, LLC
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Shavano ParkUnited StatesUnknown status
DelRicht Research
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SpringfieldUnited StatesUnknown status
Piedmont Healthcare
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StatesvilleUnited StatesUnknown status
Clinical Research Atlanta
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StockbridgeUnited StatesUnknown status
Clinical Research Institute of Arizona
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Sun City WestUnited StatesUnknown status
DM Clinical Research
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TomballUnited StatesUnknown status
University Clinical Investigators, Incorporated
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TustinUnited StatesUnknown status
Preferred Primary Care Physicians
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UniontownUnited StatesUnknown status
Preferred Primary Care Physicians, Inc.
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UniontownUnited StatesUnknown status
DelRicht Research
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ViennaUnited StatesUnknown status
Diablo Clinical Research, LLC dba Flourish Research
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Walnut CreekUnited StatesUnknown status
Accellacare - Wilmington
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WilmingtonUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.