NCT07575932Active, not recruitingPhase 2
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity
A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE-RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 940 (actual)
- First submitted
- 4 May 2026
- Start date
- 11 May 2026
- Primary completion date
- 4 Aug 2027
- Lead sponsor
- Pfizer
- Diseases
- Obesity
- NCT number
- NCT07575932
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 940
- From 11 May 2026 to the primary completion date, 4 Aug 2027
- 63 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who are not eligible include those with diabetes mellitus, a body weight change of \>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.
Who the study is looking for
- Eligible participants for this study include:
- adults aged 18 years or older with
- obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with
- overweight (BMI of 27.0 kg/m2 to \<30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (63)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aggarwal and Associates Limited Coordinator of this site? Confirm its status | Brampton | Canada | Unknown status |
| Viable Clinical Research Corporation Coordinator of this site? Confirm its status | Bridgewater | Canada | Unknown status |
| Ecogene-21 Coordinator of this site? Confirm its status | Chicoutimi | Canada | Unknown status |
| Centricity Research Etobicoke Endocrinology Coordinator of this site? Confirm its status | Etobicoke | Canada | Unknown status |
| Milestone Research Inc. Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Centricity Research Mirabel Multispecialty Coordinator of this site? Confirm its status | Mirabel | Canada | Unknown status |
| Recherche GCP Research Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Bluewater Clinical Research Group Inc. Coordinator of this site? Confirm its status | Sarnia | Canada | Unknown status |
| Centricity Research Toronto Manna Multispecialty Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Dr. Anil K. Gupta Medicine Professional Corporation Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Washington Center for Weight Management and Research Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Atlanta Diabetes Associates Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Mercury Street Medical Group, PLLC Coordinator of this site? Confirm its status | Butte | United States | Unknown status |
| San Fernando Valley Health Institute Coordinator of this site? Confirm its status | Canoga Park | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Cedar Health Research - Euless Coordinator of this site? Confirm its status | Euless | United States | Unknown status |
| Ark Clinical Research Coordinator of this site? Confirm its status | Fountain Valley | United States | Unknown status |
| Paragon Rx Clinical Coordinator of this site? Confirm its status | Garden Grove | United States | Unknown status |
| Bioluminux Clinical Research Coordinator of this site? Confirm its status | Hamilton | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Hendersonville | United States | Unknown status |
| AGA Clinical Trials Coordinator of this site? Confirm its status | Hialeah | United States | Unknown status |
| JCCT- Juno NW Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Westside Center for Clinical Research Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Activian Clinical Research Coordinator of this site? Confirm its status | Kingwood | United States | Unknown status |
| AB Clinical Trials Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Alliance Clinical Research Las Vegas (Excel Clinical Research) Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Palm Research Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Johnson County Clinical Trials Coordinator of this site? Confirm its status | Lenexa | United States | Unknown status |
| Torrance Clinical Research Institute, Inc. Coordinator of this site? Confirm its status | Lomita | United States | Unknown status |
| Ark Clinical Research Coordinator of this site? Confirm its status | Long Beach | United States | Unknown status |
| Collaborative Neuroscience Research, LLC Coordinator of this site? Confirm its status | Los Alamitos | United States | Unknown status |
| Patient First Clinical Trials (PFCTRIALS) Coordinator of this site? Confirm its status | Lutherville | United States | Unknown status |
| Manassas Clinical Research Center Coordinator of this site? Confirm its status | Manassas | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Mandeville | United States | Unknown status |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Paradigm Clinical Research - Modesto Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Monroe Biomedical Research Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Koch Family Medicine Clinical Research/Elite Research Network Coordinator of this site? Confirm its status | Morton | United States | Unknown status |
| TMA Headlands LLC (d/b/a Trial Management Associates) Coordinator of this site? Confirm its status | Myrtle Beach | United States | Unknown status |
| Bioluminux Clinical Research Illinois Coordinator of this site? Confirm its status | Naperville | United States | Unknown status |
| Tekton Research, LLC. Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Charter Research Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Preferred Primary Care Physicians Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| 3A Research Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Prairieville | United States | Unknown status |
| DelRicht Research @ Zomnir Family Medicine Coordinator of this site? Confirm its status | Prosper | United States | Unknown status |
| Alpine Medical Group Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Wasatch Clinical Research, LLC Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Worldwide Clinical Trials Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Tekton Research, LLC Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Paradigm Clinical Research Centers, LLC Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Consano Clinical Research, LLC Coordinator of this site? Confirm its status | Shavano Park | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Piedmont Healthcare Coordinator of this site? Confirm its status | Statesville | United States | Unknown status |
| Clinical Research Atlanta Coordinator of this site? Confirm its status | Stockbridge | United States | Unknown status |
| Clinical Research Institute of Arizona Coordinator of this site? Confirm its status | Sun City West | United States | Unknown status |
| DM Clinical Research Coordinator of this site? Confirm its status | Tomball | United States | Unknown status |
| University Clinical Investigators, Incorporated Coordinator of this site? Confirm its status | Tustin | United States | Unknown status |
| Preferred Primary Care Physicians Coordinator of this site? Confirm its status | Uniontown | United States | Unknown status |
| Preferred Primary Care Physicians, Inc. Coordinator of this site? Confirm its status | Uniontown | United States | Unknown status |
| DelRicht Research Coordinator of this site? Confirm its status | Vienna | United States | Unknown status |
| Diablo Clinical Research, LLC dba Flourish Research Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Accellacare - Wilmington Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.