NCT07577609Recruiting
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
Artificial Intelligence-assisted CT for Risk Stratification in COronary Artery Disease to PreveNt Future Coronary Events and Improve Outcomes
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated cardiac CT. The main questions it aims to answer are: * Can AI-enhanced cardiac CT accurately assess cardiovascular risk in a real-world adult population? * How do CT-derived plaque characteristics correlate with clinical, biochemical, and lifestyle risk factors? Researchers will compare subgroups (e.g., patients with different risk profiles, biomarkers, or imaging findings, and a subset undergoing OCT imaging) to see if differences in imaging and clinical parameters are associated with cardiovascular risk and plaque vulnerability. Participants will: * Provide informed consent and medical history/demographic information * Undergo blood sampling for cardiovascular and metabolic biomarkers * Have a resting ECG performed * Complete a detailed lifestyle and health questionnaire * Receive a non-invasive cardiac CT scan interpreted by an expert * Potentially receive heart rate-lowering medication (e.g., metoprolol) if required for imaging quality * Be referred for further clinical evaluation if clinically indicated 
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 10000 (estimated)
- First submitted
- 28 Apr 2026
- Start date
- 21 Dec 2022
- Primary completion date
- 21 Dec 2032
- Lead sponsor
- University of Galway
- Diseases
- Coronary artery disease
- NCT number
- NCT07577609
What you commit to
- Study type: Observational
- Planned participants: 10000
- From 21 Dec 2022 to the primary completion date, 21 Dec 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of malignancy
Lab values
- Abnormal renal function (e.g., eGFR or serum creatinine outside reference range)
Other
- Contraindications to iodinated contrast agents or CT imaging
Who the study is looking for
- Adults aged ≥18 years
- Undergoing clinically indicated cardiac CT
- Able and willing to provide informed consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Research Facility Coordinator of this site? Confirm its status | Galway | Ireland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.