NCT07580183Recruiting
Spatial Scene Recognition Memory in Epilepsy Surgery
Investigations of Spatial Recognition Memory to Improve Cognitive Outcomes in Epilepsy Surgery
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 620 (estimated)
- First submitted
- 30 Apr 2026
- Start date
- 1 Jul 2024
- Primary completion date
- 30 Jun 2030
- Lead sponsor
- University of California, Davis
- Diseases
- Epilepsy
- NCT number
- NCT07580183
What you commit to
- Study type: Interventional
- Planned participants: 620
- From 1 Jul 2024 to the primary completion date, 30 Jun 2030
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)
Age
- For Aim III: Age \> 55 years
Other
- Full-Scale IQ \< 70
- Inability to provide informed consent
Who the study is looking for
- Age 18 years or older
- For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery
- For Aim II: Healthy adult participants
- Full-Scale IQ ≥ 70
- English proficiency sufficient to understand and complete the task
- For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry
- For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center
- Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry)
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| UC Davis Medical Center Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.