NCT07580547Recruiting
Sex-Based Disparities in the Electrophysiological Substrate for Atrial Fibrillation and Its Impact on Clinical Outcomes
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
DISPARITY-AF is a prospective, single-center, observational registry designed to characterize the sex-based disparities in the electrophysiological substrate driving Atrial Fibrillation (AF). While standard Pulmonary Vein Isolation (PVI) is the cornerstone of AF ablation, women consistently experience lower long-term success rates. This study tests the hypothesis that women harbor a significantly higher burden of unmapped, extra-pulmonary vein (extra-PV) AF initiation sites compared to men. In 100 consecutive patients undergoing first-time PVI, comprehensive biatrial repolarization mapping will be performed using programmed electrical stimulation (PES) to measure the atrial effective refractory period (AERP) in multiple atrial sites immediately after successful PVI. All mapping systems and multielectrode catheters utilized in this study are clinically approved and used routinely in our center. Identified steep repolarization gradients (SRGs) and AF initiation sites will be documented but not ablated. Patients will undergo intensive 1-year clinical follow-up to test the secondary hypothesis that patients with untreated extra-PV SRG/AF initiation sites have a significantly higher rate of AF recurrence.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 28 Apr 2026
- Start date
- May 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- Anat Milman
- Diseases
- Atrial fibrillation
- NCT number
- NCT07580547
What you commit to
- Study type: Interventional
- Planned participants: 100
- From May 2026 to the primary completion date, Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior catheter ablation for AF or surgical MAZE.
Other
- Long-standing persistent AF (\>12 months).
- Presence of intracardiac thrombus or contraindication to systemic anticoagulation.
- Pregnant women and patients not able to provide an informed consent
Who the study is looking for
- Age between 18 and 80 years.
- Male or Female sex.
- Symptomatic paroxysmal or persistent AF indicated for a first-time catheter ablation.
- Ability to provide written informed consent.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shamir Medical Center Coordinator of this site? Confirm its status | Be’er Ya‘aqov | Israel | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.