NCT07583329Not yet recruiting
Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) and Conventional Laparoscopy
Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With V-NOTES and Conventional Laparoscopy: A Multicenter Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 20 May 2026
Brief summary (registry, in English)
Endometrial cancer is a common cancer in women, and surgery is usually the first step in treatment. During surgery, doctors often check nearby lymph nodes to see if the cancer has spread. A newer method called sentinel lymph node (SLN) mapping allows doctors to examine only the first few lymph nodes most likely to contain cancer. This can reduce the need for removing many lymph nodes and may lower the risk of complications. Minimally invasive surgery is commonly performed using small abdominal incisions (laparoscopy). A newer technique, called vaginal natural orifice transluminal endoscopic surgery (vNOTES), allows the surgery to be performed through the vagina without any cuts on the abdomen. This approach may lead to less pain, quicker recovery, and no visible scars. This study will compare these two surgical methods-laparoscopy and vNOTES-in patients with early-stage endometrial cancer. Researchers will look at how safe and effective each method is, how patients recover after surgery, and how well the sentinel lymph node procedure works with each technique. The study will also examine how quickly surgeons become experienced with the newer vNOTES method. The goal of this research is to determine whether vNOTES can be a safe and effective alternative to standard laparoscopic surgery, while offering potential benefits for patients.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 160 (estimated)
- First submitted
- 22 Apr 2026
- Start date
- 19 May 2026
- Primary completion date
- 30 Apr 2028
- Lead sponsor
- Cukurova University
- Diseases
- Endometrial cancer
- NCT number
- NCT07583329
What you commit to
- Study type: Observational
- Planned participants: 160
- From 19 May 2026 to the primary completion date, 30 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Surgery performed via an open (laparotomy) approach
- History of prior pelvic radiotherapy
Other illness
- Presence of extrauterine disease
Other
- Detection of distant metastasis
- Incomplete medical records
Who the study is looking for
- Age ≥18 years
- Histologically confirmed endometrial cancer on preoperative endometrial biopsy
- Disease confirmed to be confined to the uterus based on clinical evaluation and imaging
- No evidence of lymphatic or distant metastasis on positron emission tomography/computed tomography(PET/CT) or magnetic resonance imaging (MRI)
- Surgical staging with sentinel lymph node biopsy recommended by a multidisciplinary tumor board
- Surgical treatment performed using either conventional laparoscopy or the vNOTES approach
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cukurova Univercity Coordinator of this site? Confirm its status | Adana | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.