NCT07583927Enrolling by invitation
Anemia on Sublingual Microcirculation in GDFT
Effects of Anemia on Sublingual Microcirculation in Patients Undergoing Goal-Directed Fluid Therapy: A Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 13 May 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about the effects of anemia on sublingual microcirculation in patients undergoing goal-directed fluid therapy (GDFT) during surgery. The main question it aims to answer is: Does anemia, under the condition of goal-directed fluid therapy, lead to significant changes in sublingual microcirculatory parameters (such as microvascular density and perfusion)? Participants will include 54 patients scheduled for elective open radical gastrectomy (27 anemic vs. 27 non-anemic). Sublingual microcirculation will be assessed using a side-stream dark field imaging device at four time points: before anesthesia induction (T0), after induction (T1), after specimen removal (T2), and after anastomosis completion (T3). All patients will receive intraoperative GDFT guided by pulse pressure variation (PPV) and cardiac output (CO) via the Vigileo-FloTrac system.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 54 (estimated)
- First submitted
- 7 May 2026
- Start date
- May 2026
- Primary completion date
- Jul 2026
- Lead sponsor
- Fudan University
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT07583927
What you commit to
- Study type: Observational
- Planned participants: 54
- From May 2026 to the primary completion date, Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Scheduled for laparoscopic surgery
- Inability to position or observe the patient's head during surgery
- Hemodynamic instability during surgery
Other illness
- Untreated ischemic heart disease or severe cardiovascular disease
- Acute or chronic respiratory failure, severe asthma, pulmonary bullae, pneumothorax, emphysema, bronchopleural fistula
- Oral or tongue disorders
Other
- Refusal to participate after entering the operating room
- Intraoperative life-threatening events
Who the study is looking for
- Scheduled for elective open radical gastrectomy
- Age ≥ 18 years
- ASA physical status I-III
- Undergoing general anesthesia with endotracheal intubation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Cancer Center, Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
Related publications
- Alteration of sublingual microcirculation in anemic patients during gastric cancer surgery under goal-directed fluid therapy: a prospective cohort study.J Clin Monit Comput · 2026 · PMID 42879041
This page is information, not medical advice. Discuss any trial with your doctor.