NCT07585331Completed
Towards Effective, Patient-tailored Anti-plasma Cell Therapies in AL Amyloidosis: Predicting Drug Response and Overcoming Drug Resistance
Source: ClinicalTrials.gov · Last updated 13 May 2026
Brief summary (registry, in English)
Through an observational clinical study, partly prospective and partly retrospective, based on the collection of clinical data and on in vitro experimental analyses carried out on residual biological samples obtained during routine clinical procedures, it is proposed to identify predictive biomarkers of in vivo response to first-line therapies.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 250 (actual)
- First submitted
- 7 May 2026
- Start date
- 13 Jan 2022
- Primary completion date
- 30 Mar 2026
- Lead sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
- Diseases
- Amyloidosis
- NCT number
- NCT07585331
What you commit to
- Study type: Observational
- Participants enrolled: 250
- From 13 Jan 2022 to the primary completion date, 30 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous anti-plasma cell therapy
Other illness
- Failure to show willingness to allow use of clinical data and diagnostic leftovers of clinical specimens for research purposes.
Age
- Age \<18 years
Other
- Non-AL amyloidosis
- IgM clone
Who the study is looking for
- Biopsy-proven systemic AL amyloidosis
- No IgM clone
- No history of anti-plasma cell therapy
- Diagnostic bone marrow aspiration at ARTC
- Age \> 18 years
- Willingness to allow use of clinical data and diagnostic leftovers of clinical specimens for research purposes through signing a written informed consent.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione IRCCS Policlinico San Matteo Coordinator of this site? Confirm its status | Pavia | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.