NCT07588295Recruiting
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Apr 2026
- Start date
- 18 Mar 2024
- Primary completion date
- Dec 2026
- Lead sponsor
- Maria Cecilia Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07588295
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 18 Mar 2024 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antinflammatory drugs
- Recent surgical procedures
Other illness
- Severe valve disease
- Advanced heart failure
- Advanced liver disease
- Chronic inflammatory or autoimmune disease
- Acute infection
Other
- Severe renal dysfunction
Who the study is looking for
- Patients with chronic coronary artery disease;
- Patients with no-ST elevation acute coronary syndrome;
- Patients with chronic claudication (Rutherford II-III)
- Patients with critical limb ischemia (Rutherford IV-V).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Maria Cecilia Hospital Coordinator of this site? Confirm its status | Cotignola | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.