NCT07589296Recruiting
Robot-Assisted Gait Training vs NMES in Parkinson's Disease
Comparative Effects of Robot-Assisted Gait Training and Quadriceps Neuromuscular Electrical Stimulation Added to Standard Exercise Rehabilitation on Balance, Gait, Disease Severity, and Quadriceps Muscle Adaptations in Patients With Parkinson Disease: A Prospective Randomized Assessor-Blinded Clinical Trial
Source: ClinicalTrials.gov · Last updated 15 May 2026
Brief summary (registry, in English)
This prospective, randomized, assessor-blinded clinical trial aims to compare the effects of robot-assisted gait training and quadriceps neuromuscular electrical stimulation (NMES) when added to a standard exercise rehabilitation program in patients with Parkinson disease. Participants will be randomly assigned to two parallel groups. Both groups will receive a standard rehabilitation program, while one group will additionally undergo robot-assisted gait training and the other group will receive quadriceps NMES. The interventions will be administered five days per week for six weeks. Clinical outcomes, including balance, functional mobility, gait performance, and disease severity, will be evaluated at baseline, post-treatment, and follow-up (week 14). In addition, ultrasound-based assessments of quadriceps muscle thickness and cross-sectional area will be performed to investigate muscle adaptations. The results of this study are expected to provide comparative evidence regarding the effectiveness of these two rehabilitation approaches and contribute to optimizing rehabilitation strategies in Parkinson disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 3 May 2026
- Start date
- 15 Apr 2026
- Primary completion date
- 15 Apr 2026
- Lead sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
- Diseases
- Parkinson disease
- NCT number
- NCT07589296
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 15 Apr 2026 to the primary completion date, 15 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe cognitive impairment or inability to follow instructions
- Hoehn and Yahr stage IV-V Parkinson's disease
- Severe musculoskeletal disorders affecting gait (e.g., advanced osteoarthritis, recent fracture)
- History of lower extremity surgery within the last 6 months
- Severe cardiovascular or respiratory disease limiting exercise participation
- Presence of other neurological disorders affecting mobility (e.g., stroke, multiple sclerosis)
- Skin lesions or infections at electrode placement sites
Other
- Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)
- Participation in another structured rehabilitation program within the last 3 months
Who the study is looking for
- Diagnosis of Parkinson's disease according to established clinical criteria
- Age between 40 and 80 years
- Hoehn and Yahr stage II-III
- Ability to walk independently with or without assistive devices
- Stable medical treatment for at least 4 weeks prior to study enrollment
- Ability to understand and follow instructions
- Willingness to participate and provide written informed consent
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey Coordinator of this site? Confirm its status | Küçükçekmece | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.