NCT07589361Not yet recruiting
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation (VBS-CSI) With Proton Therapy in Pediatric Tumors: A Single-Center Prospective Observational Cohort Study
Source: ClinicalTrials.gov · Last updated 15 May 2026
Brief summary (registry, in English)
his is a single-center, prospective observational study in children and adolescents with central nervous system tumors who need whole-brain and whole-spine radiation therapy (craniospinal irradiation, CSI). The study uses proton therapy with a special vertebral body-sparing (VBS) technique to protect the front and center of the vertebrae, which helps preserve bone marrow function and growth. The main goals are to find safe dose limits for the vertebrae and check how often severe side effects occur. The study will also look at bone marrow preservation, spinal deformity, tumor control, survival, chemotherapy completion, neurocognitive function, quality of life, and growth and development for up to 5 years after treatment.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 38 (estimated)
- First submitted
- 29 Apr 2026
- Start date
- 30 Apr 2026
- Primary completion date
- 30 Jun 2029
- Lead sponsor
- Ruijin Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT07589361
What you commit to
- Study type: Observational
- Planned participants: 38
- From 30 Apr 2026 to the primary completion date, 30 Jun 2029
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous receipt of any form of spinal radiotherapy.
- Previous major spinal surgery for any reason.
- Presence of medical contraindications to proton radiotherapy.
Other illness
- Presence of any severe, uncontrolled systemic disease (e.g., active infection, severe cardiac, hepatic, renal, or respiratory insufficiency) that, in the investigator's judgment, makes the subject unsuitable for treatment under this protocol.
- Presence of any severe cognitive or psychiatric disorder that prevents understanding of or cooperation with study assessments.
Other
- Presence of clinically significant and confirmed spinal deformity at enrollment (e.g., Cobb angle \> 10° measured by MRI or X-ray).
- Female patients who are pregnant or breastfeeding.
Who the study is looking for
- The patient's legal guardian voluntarily signs the written informed consent form.
- Age at diagnosis \> 3 years and ≤ 18 years.
- Histopathologically confirmed diagnosis of a central nervous system (CNS) tumor.
- Indication for craniospinal irradiation (CSI) confirmed by multidisciplinary team (MDT) discussion.
- Karnofsky Performance Score (KPS) ≥ 80.
- For postoperative patients, complete healing of the surgical incision with no evidence of wound infection or other complications.
- For women of childbearing potential, effective contraception must be used for at least one month prior to screening, and they must commit to continued contraception throughout the study period and for the required time after study completion.
Age in the registry: 4 years to 18 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.