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NCT07589608RecruitingPhase 2

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes

Source: ClinicalTrials.gov · Last updated 8 Oct 2026

Brief summary (registry, in English)

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
400 (estimated)
First submitted
11 May 2026
Start date
15 May 2026
Primary completion date
30 Sept 2027
Lead sponsor
Eli Lilly and Company
NCT number
NCT07589608

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 400
  • From 15 May 2026 to the primary completion date, 30 Sept 2027
  • 40 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • All concomitant medications should be at a stable dose for at least 3 months prior to screening

Other illness

  • Have type 1 diabetes or type 2 diabetes
  • Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
  • Have a history of acute or chronic pancreatitis

Other

  • In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):
  • Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)

Who the study is looking for

  • See Master Protocol CWMM (NCT06143956) for inclusion criteria

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (40)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Dent Neurologic Institute
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AmherstUnited StatesRecruiting
Medical Research Partners
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AmmonUnited StatesRecruiting
IMA Clinical Research Austin
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AustinUnited StatesRecruiting
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
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ChandlerUnited StatesRecruiting
Great Lakes Clinical Trials - Ravenswood
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ChicagoUnited StatesRecruiting
CTI Clinical Research Center
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CincinnatiUnited StatesRecruiting
StudyMetrix Research
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City of Saint PetersUnited StatesRecruiting
FutureSearch Trials of Dallas
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DallasUnited StatesRecruiting
Sovah Clinical Research-River District
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DanvilleUnited StatesRecruiting
NorCal Medical Research, Inc
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GreenbraeUnited StatesRecruiting
Medication Management
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GreensboroUnited StatesRecruiting
Tribe Clinical Research LLC
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GreenvilleUnited StatesRecruiting
PlanIt Research, PLLC
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HoustonUnited StatesRecruiting
Velocity Clinical Research-Huntington Park
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Huntington ParkUnited StatesRecruiting
Las Vegas Medical Research
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Las VegasUnited StatesRecruiting
Monroe Biomedical Research - Louisville
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LouisvilleUnited StatesRecruiting
New Horizon Research Center
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MiamiUnited StatesRecruiting
Indago Research & Health Center, Inc
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Miami LakesUnited StatesRecruiting
Monroe Biomedical Research
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MonroeUnited StatesRecruiting
Lucas Research, Inc.
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Morehead CityUnited StatesRecruiting
Quality Medical Research
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NashvilleUnited StatesRecruiting
Knownwell
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NeedhamUnited StatesRecruiting
Lucida Clinical Trials
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New BedfordUnited StatesRecruiting
Lucas Research, Inc.
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New BernUnited StatesRecruiting
Suncoast Clinical Research, Inc.
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New Port RicheyUnited StatesRecruiting
Charter Research - Winter Park
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OrlandoUnited StatesRecruiting
Rochester Clinical Research, LLC
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RochesterUnited StatesRecruiting
Peninsula Research Associates
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Rolling Hills EstatesUnited StatesRecruiting
Endeavor Clinical Trials
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San AntonioUnited StatesRecruiting
Headlands Research - Scottsdale
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ScottsdaleUnited StatesRecruiting
Headlands Research - Detroit
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SouthfieldUnited StatesRecruiting
Clinvest Headlands LLC
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SpringfieldUnited StatesRecruiting
Stamford Therapeutics Consortium
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StamfordUnited StatesRecruiting
Charter Research - Lady Lake
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The VillagesUnited StatesRecruiting
Cotton O'Neil Diabetes & Endocrinology
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TopekaUnited StatesRecruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
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TroyUnited StatesRecruiting
The Institute for Liver Health II dba Arizona Liver Health-Tucson
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TucsonUnited StatesRecruiting
Diablo Clinical Research, Inc.
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Walnut CreekUnited StatesRecruiting
Central Washington Health Services Association d/b/a Confluence Health
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WenatcheeUnited StatesRecruiting
Texas Valley Clinical Research
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WeslacoUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.