NCT07589608RecruitingPhase 2
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 11 May 2026
- Start date
- 15 May 2026
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07589608
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 400
- From 15 May 2026 to the primary completion date, 30 Sept 2027
- 40 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- All concomitant medications should be at a stable dose for at least 3 months prior to screening
Other illness
- Have type 1 diabetes or type 2 diabetes
- Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
- Have a history of acute or chronic pancreatitis
Other
- In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):
- Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
Who the study is looking for
- See Master Protocol CWMM (NCT06143956) for inclusion criteria
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (40)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dent Neurologic Institute Coordinator of this site? Confirm its status | Amherst | United States | Recruiting |
| Medical Research Partners Coordinator of this site? Confirm its status | Ammon | United States | Recruiting |
| IMA Clinical Research Austin Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| The Institute for Liver Health II dba Arizona Clinical Trials - Mesa Coordinator of this site? Confirm its status | Chandler | United States | Recruiting |
| Great Lakes Clinical Trials - Ravenswood Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| CTI Clinical Research Center Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| StudyMetrix Research Coordinator of this site? Confirm its status | City of Saint Peters | United States | Recruiting |
| FutureSearch Trials of Dallas Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Sovah Clinical Research-River District Coordinator of this site? Confirm its status | Danville | United States | Recruiting |
| NorCal Medical Research, Inc Coordinator of this site? Confirm its status | Greenbrae | United States | Recruiting |
| Medication Management Coordinator of this site? Confirm its status | Greensboro | United States | Recruiting |
| Tribe Clinical Research LLC Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
| PlanIt Research, PLLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Velocity Clinical Research-Huntington Park Coordinator of this site? Confirm its status | Huntington Park | United States | Recruiting |
| Las Vegas Medical Research Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| Monroe Biomedical Research - Louisville Coordinator of this site? Confirm its status | Louisville | United States | Recruiting |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Indago Research & Health Center, Inc Coordinator of this site? Confirm its status | Miami Lakes | United States | Recruiting |
| Monroe Biomedical Research Coordinator of this site? Confirm its status | Monroe | United States | Recruiting |
| Lucas Research, Inc. Coordinator of this site? Confirm its status | Morehead City | United States | Recruiting |
| Quality Medical Research Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Knownwell Coordinator of this site? Confirm its status | Needham | United States | Recruiting |
| Lucida Clinical Trials Coordinator of this site? Confirm its status | New Bedford | United States | Recruiting |
| Lucas Research, Inc. Coordinator of this site? Confirm its status | New Bern | United States | Recruiting |
| Suncoast Clinical Research, Inc. Coordinator of this site? Confirm its status | New Port Richey | United States | Recruiting |
| Charter Research - Winter Park Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Rochester Clinical Research, LLC Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Peninsula Research Associates Coordinator of this site? Confirm its status | Rolling Hills Estates | United States | Recruiting |
| Endeavor Clinical Trials Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| Headlands Research - Scottsdale Coordinator of this site? Confirm its status | Scottsdale | United States | Recruiting |
| Headlands Research - Detroit Coordinator of this site? Confirm its status | Southfield | United States | Recruiting |
| Clinvest Headlands LLC Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Stamford Therapeutics Consortium Coordinator of this site? Confirm its status | Stamford | United States | Recruiting |
| Charter Research - Lady Lake Coordinator of this site? Confirm its status | The Villages | United States | Recruiting |
| Cotton O'Neil Diabetes & Endocrinology Coordinator of this site? Confirm its status | Topeka | United States | Recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division Coordinator of this site? Confirm its status | Troy | United States | Recruiting |
| The Institute for Liver Health II dba Arizona Liver Health-Tucson Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Recruiting |
| Central Washington Health Services Association d/b/a Confluence Health Coordinator of this site? Confirm its status | Wenatchee | United States | Recruiting |
| Texas Valley Clinical Research Coordinator of this site? Confirm its status | Weslaco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.