NCT07589647Recruiting
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disordercomorbid With Obesity
Source: ClinicalTrials.gov · Last updated 27 May 2026
Brief summary (registry, in English)
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention. It intends to investigate the changes in key metabolic molecules such as GLP-1 circadian rhythm, and further explore the molecular mechanism of their metabolic disorders.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 11 May 2026
- Start date
- 27 Apr 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- First Affiliated Hospital of Zhejiang University
- Diseases
- Obesity, Bipolar disorder
- NCT number
- NCT07589647
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 27 Apr 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Those who consumed food or microecological preparations containing probiotics, prebiotics, etc. within one week before enrollment, and had a history of respiratory, urinary, digestive system infections and antibiotic use within one month before enrollment;
Other illness
- Individuals with other DSM-5 spectrum disorders;
- Mental disorders caused by substance abuse (such as alcohol, drugs, etc.), and those with severe physical illnesses;
- Those who cannot complete MRI examinations due to special conditions such as having metal implants or pacemakers in their bodies.
Other
- 221/5000
- Those currently having serious suicidal thoughts or behaviors, or those with severe agitation;
- Those who cannot follow medical advice for treatment, or those without guardians;
- Pregnant or lactating women, or those planning to become pregnant;
Who the study is looking for
- Both biological parents are of Han ethnicity;
- Age range: 18 to 45 years old, gender not restricted;
- Meets the clinical diagnostic criteria for bipolar disorder as stipulated in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5);
- Body Mass Index (BMI) ≥ 28 kg/m2, or for males, waist circumference ≥ 90 cm and for females, waist circumference ≥ 85 cm;
- HAMD-24 score \< 7 points, YMRS score \< 5 points;
- All included researchers and their family members have given informed consent for this study.
Age in the registry: 18 years to 45 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| First Affiliated Hospital of Zhejiang University Coordinator of this site? Confirm its status | Hangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.