NCT07590193RecruitingPhase 1
A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
A Phase 1 Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Source: ClinicalTrials.gov · Last updated 3 Aug 2026
Brief summary (registry, in English)
The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 162 (estimated)
- First submitted
- 11 May 2026
- Start date
- 11 Jun 2026
- Primary completion date
- 2 Oct 2027
- Lead sponsor
- Amgen
- Diseases
- Type 1 diabetes, Type 2 diabetes
- NCT number
- NCT07590193
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 162
- From 11 Jun 2026 to the primary completion date, 2 Oct 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of hypotension, syncope, or orthostatic intolerance
- History of hypotension, syncope, or orthostatic intolerance
Lab values
- Hemoglobin A1c (HbA1c) \>10% within the last 3 months
Other
- Systolic blood pressure \>140 millimeters of mercury (mmHg) or diastolic blood pressure \>90 mmHg
- Systolic blood pressure \>160 mmHg or diastolic blood pressure \>100 mmHg
Who the study is looking for
- Participant must be 18-65 years of age
- Participant must be overtly healthy
- Participant must be 40-75 years of age
- Confirmed diagnoses of T2DM
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Translational Clinical Research LLC Coordinator of this site? Confirm its status | Aventura | United States | Recruiting |
| Orange County Research Center Coordinator of this site? Confirm its status | Lake Forest | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.