Fact CheckerSign in

NCT07592689RecruitingPhase 3

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Ascend

Source: ClinicalTrials.gov · Last updated 23 Oct 2026

Brief summary (registry, in English)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
165 (estimated)
First submitted
12 May 2026
Start date
10 May 2026
Primary completion date
Sept 2027
Lead sponsor
Definium Therapeutics US, Inc.
Diseases
Depression
NCT number
NCT07592689

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 165
  • From 10 May 2026 to the primary completion date, Sept 2027
  • 30 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Certain psychiatric disorders (other than major depressive disorder)
  • First degree relative with or lifetime history of a psychotic disorder or bipolar disorder
  • Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine
  • Any clinically significant unstable illness

Who the study is looking for

  • Diagnosis of MDD per DSM-5
  • Male or female aged 18 to 74
  • Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration
  • MADRS Total Score ≥26
  • CGI-S Score ≥4

Age in the registry: 18 years to 74 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (30)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
CenExel - Atlanta Center for Medical Research
Coordinator of this site? Confirm its status
AtlantaUnited StatesRecruiting
Austin Clinical Trial Partners
Coordinator of this site? Confirm its status
AustinUnited StatesRecruiting
Memory Clinic, Inc.
Coordinator of this site? Confirm its status
BenningtonUnited StatesRecruiting
Adams Clinical Watertown
Coordinator of this site? Confirm its status
BostonUnited StatesRecruiting
Adams Clinical Boston
Coordinator of this site? Confirm its status
BostonUnited StatesActive, not recruiting
Uptown Research Institute
Coordinator of this site? Confirm its status
ChicagoUnited StatesRecruiting
Cleveland Clinic
Coordinator of this site? Confirm its status
ClevelandUnited StatesNot yet recruiting
CenExel - iResearch Atlanta
Coordinator of this site? Confirm its status
DecaturUnited StatesRecruiting
Mountain View Clinical Research, Inc
Coordinator of this site? Confirm its status
DenverUnited StatesRecruiting
Cedar Clinical Research
Coordinator of this site? Confirm its status
DraperUnited StatesRecruiting
Clinical Neuroscience Solutions, LLC (Jacksonville)
Coordinator of this site? Confirm its status
JacksonvilleUnited StatesRecruiting
Redbird Research
Coordinator of this site? Confirm its status
Las VegasUnited StatesRecruiting
Preferred Research Partners, Inc
Coordinator of this site? Confirm its status
Little RockUnited StatesRecruiting
K2 Medical Research - Maitland
Coordinator of this site? Confirm its status
MaitlandUnited StatesRecruiting
Adams Clinical Harlem
Coordinator of this site? Confirm its status
New YorkUnited StatesActive, not recruiting
Coastal Carolina Research
Coordinator of this site? Confirm its status
North CharlestonUnited StatesRecruiting
ATP Clinical Research Orange County
Coordinator of this site? Confirm its status
OrangeUnited StatesRecruiting
Inner Space Research
Coordinator of this site? Confirm its status
OremUnited StatesRecruiting
Charter Research
Coordinator of this site? Confirm its status
OrlandoUnited StatesNot yet recruiting
Clinical Neuroscience Solutions, LLC (Orlando)
Coordinator of this site? Confirm its status
OrlandoUnited StatesRecruiting
Adams Clinical Philadelphia
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesRecruiting
Kadima Neuropsychiatry Institute
Coordinator of this site? Confirm its status
San DiegoUnited StatesRecruiting
UCSF Department of Neurology
Coordinator of this site? Confirm its status
San FranciscoUnited StatesNot yet recruiting
Psychedelic Science Institute
Coordinator of this site? Confirm its status
Santa MonicaUnited StatesRecruiting
Cenexel Iresearch - Savannah
Coordinator of this site? Confirm its status
SavannahUnited StatesRecruiting
Seattle Neuropsychiatric Treatment Center
Coordinator of this site? Confirm its status
SeattleUnited StatesNot yet recruiting
Arch Clinical Trials, LLC
Coordinator of this site? Confirm its status
St LouisUnited StatesRecruiting
K2 Medical Research - Tampa
Coordinator of this site? Confirm its status
TampaUnited StatesRecruiting
VA Portland Healthcare System
Coordinator of this site? Confirm its status
VancouverUnited StatesNot yet recruiting
Vitalix Clinical
Coordinator of this site? Confirm its status
WorcesterUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.