NCT07592689RecruitingPhase 3
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Ascend
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 165 (estimated)
- First submitted
- 12 May 2026
- Start date
- 10 May 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Definium Therapeutics US, Inc.
- Diseases
- Depression
- NCT number
- NCT07592689
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 165
- From 10 May 2026 to the primary completion date, Sept 2027
- 30 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Certain psychiatric disorders (other than major depressive disorder)
- First degree relative with or lifetime history of a psychotic disorder or bipolar disorder
- Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine
- Any clinically significant unstable illness
Who the study is looking for
- Diagnosis of MDD per DSM-5
- Male or female aged 18 to 74
- Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration
- MADRS Total Score ≥26
- CGI-S Score ≥4
Age in the registry: 18 years to 74 years · Sex: All · Does not accept healthy volunteers
Sites (30)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CenExel - Atlanta Center for Medical Research Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Austin Clinical Trial Partners Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Memory Clinic, Inc. Coordinator of this site? Confirm its status | Bennington | United States | Recruiting |
| Adams Clinical Watertown Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Adams Clinical Boston Coordinator of this site? Confirm its status | Boston | United States | Active, not recruiting |
| Uptown Research Institute Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Not yet recruiting |
| CenExel - iResearch Atlanta Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Mountain View Clinical Research, Inc Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| Cedar Clinical Research Coordinator of this site? Confirm its status | Draper | United States | Recruiting |
| Clinical Neuroscience Solutions, LLC (Jacksonville) Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Redbird Research Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| Preferred Research Partners, Inc Coordinator of this site? Confirm its status | Little Rock | United States | Recruiting |
| K2 Medical Research - Maitland Coordinator of this site? Confirm its status | Maitland | United States | Recruiting |
| Adams Clinical Harlem Coordinator of this site? Confirm its status | New York | United States | Active, not recruiting |
| Coastal Carolina Research Coordinator of this site? Confirm its status | North Charleston | United States | Recruiting |
| ATP Clinical Research Orange County Coordinator of this site? Confirm its status | Orange | United States | Recruiting |
| Inner Space Research Coordinator of this site? Confirm its status | Orem | United States | Recruiting |
| Charter Research Coordinator of this site? Confirm its status | Orlando | United States | Not yet recruiting |
| Clinical Neuroscience Solutions, LLC (Orlando) Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Adams Clinical Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Kadima Neuropsychiatry Institute Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| UCSF Department of Neurology Coordinator of this site? Confirm its status | San Francisco | United States | Not yet recruiting |
| Psychedelic Science Institute Coordinator of this site? Confirm its status | Santa Monica | United States | Recruiting |
| Cenexel Iresearch - Savannah Coordinator of this site? Confirm its status | Savannah | United States | Recruiting |
| Seattle Neuropsychiatric Treatment Center Coordinator of this site? Confirm its status | Seattle | United States | Not yet recruiting |
| Arch Clinical Trials, LLC Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| K2 Medical Research - Tampa Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| VA Portland Healthcare System Coordinator of this site? Confirm its status | Vancouver | United States | Not yet recruiting |
| Vitalix Clinical Coordinator of this site? Confirm its status | Worcester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.