Adebrelimab Combined With Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Prior treatment

• 1\. Patients who have received or are currently receiving chemotherapy, radiotherapy, immunotherapy, or targeted therapy
• 2\. Patients with distant metastasis or inability to undergo resection after evaluation by thoracic surgeons
• 5\. Patients with a history of autoimmune diseases who were receiving immunosuppressive therapy prior to enrollment, with immunosuppressive doses\>10 mg/day or oral prednisone for more than 2 weeks

Other illness

• 6\. Severe allergy to immune preparations

Lab values

• 4\. Severe impairment of heart, liver, and kidney function (heart function grade 3-4, ALT and/or AST exceeding the upper limit of normal by more than 1.5 times, Cr (serum creatinine) exceeding the upper limit of normal by more than 1.5 times)
• 7\. Abnormal coagulation function: (PT\>16s, APTT\>53s, TT\>21s, Fib\<1.5 g/L), bleeding tendency or during thrombolytic or anticoagulant therapy

Other

• 3\. Simultaneously developing tumors in other parts of the body
• 8\. Pregnancy or lactation period
• 9\. Other situations as judged by investigators not suitable for inclusion.;

• \- 1. Provided informed consent and sign the informed consent form;
• 2\. Male or female, Aged 18-75 years (counted on the date of signing informed consent);
• 3\. Pathological confirmed ESCC;
• 4\. Patients assessed by thoracic oncologists as resectable without distant metastasis
• 5\. Patients evaluate with clinical staging of T1-4aN1-3M0 or T3-4aN0M0(AJCC 9.0) based on imaging and pathological examination results;
• 6\. Have at least one assessable lesion according to the RECIST V1.1
• 7\. ECOG-PS score: 0-1;
• 8\. Patients with normal function of organs such as heart, brain, lungs, and kidneys who can tolerate surgery;
• 9\. With a life expectancy of ≥ 6 weeks;
• 10\. Adequate major organ function without severe hematologic, cardiac, pulmonary, hepatic, renal, or bone marrow dysfunction, and no immunodeficiency disease;