NCT07597746Not yet recruiting
"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series"
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often plateaus during the chronic phase. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown potential to enhance motor recovery by modulating cortical excitability and promoting neuroplasticity. This case series aims to investigate the effects of a combined protocol of repetitive transcranial magnetic stimulation and conventional physical therapy on motor function, balance, and quality of life in individuals with chronic post-stroke hemiplegia. Participants will undergo rTMS applied to the motor cortex in conjunction with a structured physical therapy program. Clinical outcomes will be assessed before and after the intervention to explore feasibility, safety, and potential functional benefits of the combined approach.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 6 May 2026
- Start date
- 5 Oct 2026
- Primary completion date
- 15 Oct 2026
- Lead sponsor
- Sierra Varona SL
- Diseases
- Stroke
- NCT number
- NCT07597746
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 5 Oct 2026 to the primary completion date, 15 Oct 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of pacemakers, cochlear implants, intracranial metallic implants, or other contraindications to rTMS
Other illness
- History of epilepsy or seizures
- Severe cognitive impairment or communication deficits preventing participation
- Progressive neurological disorders or unstable medical conditions
- Any condition judged by investigators to compromise safety or data valid
Other
- Participation in other experimental neurorehabilitation interventions during the study period
Who the study is looking for
- Diagnosis of first-ever unilateral ischemic or hemorrhagic stroke confirmed by neuroimaging (CT or MRI)
- Chronic post-stroke hemiplegia (≥ 6 months since stroke onset)
- Moderate to severe motor impairment of the affected lower limb (FMA-LE score between 10 and 28 points)
- Age between 18 and 75 years
- Medically stable and able to participate in a rehabilitation program
- Ability to understand study procedures and provide written informed consent
- No contraindications to repetitive transcranial magnetic stimulation (rTMS), according to current safety guidelines.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.